Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Department of Neonatology, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Acta Paediatr. 2021 Jul;110(7):2110-2118. doi: 10.1111/apa.15822. Epub 2021 Mar 15.
To estimate potential differences in neonatal metabolomic profiles at birth and at the time of newborn screening by delivery mode.
A prospective study at Women's Clinic at Landspitali-The National University Hospital of Iceland. Women having normal vaginal birth or elective caesarean section from November 2013 to April 2014 were offered participation. Blood samples from mothers before birth and umbilical cord at birth were collected and amino acids and acylcarnitines measured by tandem mass spectrometry. Results from the Newborn screening programme in Iceland were collected. Amino acids and acylcarnitines from different samples were compared by delivery mode.
Eighty three normal vaginal births and 32 elective caesarean sections were included. Mean differences at birth were higher for numerous amino acids, and some acylcarnitines in neonates born vaginally compared to elective caesarean section. Maternal blood samples and newborn screening results showed small differences that lost significance after correction for multiple testing. Many amino acids and some acylcarnitines were numerically higher in cord blood compared to maternal. Many amino acids and most acylcarnitines were numerically higher in newborn screening results compared to cord blood.
We observed transient yet distinct differences in metabolomic profiles between neonates by delivery mode.
通过分娩方式估计新生儿在出生时和新生儿筛查时代谢组学特征的潜在差异。
这是冰岛兰纳凯拉（Landspitali）-国立大学医院妇女诊所的一项前瞻性研究。2013 年 11 月至 2014 年 4 月期间，选择正常阴道分娩或择期剖宫产的女性参与研究。采集母亲产前和出生时的血样，并通过串联质谱法测量氨基酸和酰基肉碱。收集冰岛新生儿筛查计划的结果。通过分娩方式比较不同样本中的氨基酸和酰基肉碱。
共纳入 83 例正常阴道分娩和 32 例择期剖宫产。与择期剖宫产相比，阴道分娩的新生儿出生时的许多氨基酸和一些酰基肉碱的平均差异更大。母亲血液样本和新生儿筛查结果显示出微小的差异，但经过多次检验校正后，这些差异失去了统计学意义。与母体相比，脐血中的许多氨基酸和一些酰基肉碱数值更高。与脐血相比，新生儿筛查结果中的许多氨基酸和大多数酰基肉碱数值更高。
我们观察到分娩方式对新生儿代谢组学特征存在短暂而明显的差异。
