分娩方式对母血清和脐血中脂联素水平的影响：与人体测量学指标和胎儿性别之间的关系。
Adiponectin levels in maternal serum and umbilical cord blood at birth by mode of delivery: relationship to anthropometric measurements and fetal sex.
机构信息
Department of Midwifery & Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Jalal Ale Ahmad Highway, P.O.Box: 14115-111, Tehran, Iran.
Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
出版信息
BMC Pregnancy Childbirth. 2019 Oct 7;19(1):344. doi: 10.1186/s12884-019-2460-y.
BACKGROUND
The rate of cesarean section is increasing worldwide. Adiponectin is a hormone related to anti-inflammatory and anti-atherogenic effects; and it's concentrations may change in response to inflammatory situations including surgical intervention. The aim of the current study was to investigate serum adiponectin levels in maternal and umbilical cord blood according to different modes of delivery and their relationship with anthropometric measurements and fetal sex.
METHODS
The study population initially comprised 90 healthy pregnant women referred to the teaching hospital. Eventually, 40 participants in the vaginal delivery group and 35 subjects in the cesarean delivery group were recruited in to the study. Umbilical cord blood and maternal serum samples were analyzed according to the standard protocol from the manufacturer. The collected data were analyzed using SPSS-16 software. P-value < 0.05 was considered as the significance level for all tests.
RESULTS
Our results indicated a significant association between maternal adiponectin and the mode of delivery, with adiponectin levels significantly higher in vaginal delivery compared to cesarean section (P < 0.001). However, no difference was found in umbilical cord blood adiponectin between the two groups (P = 0.51). A significant positive correlation was found between maternal serum adiponectin in the first day after birth and umbilical cord blood adiponectin in the vaginal delivery group (P = 0.007). Nevertheless, this correlation was not statistically significant in the cesarean delivery group (P = 0.62). There was also no significant correlation between fetal sex and anthropometric measurements with maternal adiponectin (P = 0.44) and umbilical cord blood adiponectin (P = 0.86).
CONCLUSIONS
The result of the current study revealed that maternal adiponectin concentration was significantly higher in vaginal delivery compared to cesarean section, which might be due to the increased levels of maternal adiponectin release during labor.
背景
全球剖宫产率不断上升。脂联素是一种与抗炎和抗动脉粥样硬化作用相关的激素；其浓度可能会因包括手术干预在内的炎症情况而发生变化。本研究旨在探讨不同分娩方式的产妇和脐血中脂联素水平及其与人体测量学指标和胎儿性别之间的关系。
方法
本研究最初纳入了 90 名就诊于教学医院的健康孕妇。最终，40 名阴道分娩组和 35 名剖宫产组的参与者被纳入研究。按照制造商的标准方案分析脐血和产妇血清样本。使用 SPSS-16 软件分析收集的数据。所有检验的显著性水平均为 P 值<0.05。
结果
我们的结果表明，产妇脂联素与分娩方式之间存在显著关联，阴道分娩组的脂联素水平明显高于剖宫产组（P<0.001）。然而，两组之间脐血脂联素无差异（P=0.51）。阴道分娩组产妇产后第 1 天血清脂联素与脐血脂联素之间存在显著正相关（P=0.007）。然而，在剖宫产组中，这种相关性无统计学意义（P=0.62）。胎儿性别和人体测量学指标与产妇脂联素（P=0.44）和脐血脂联素（P=0.86）之间也无显著相关性。
结论
本研究结果表明，阴道分娩组产妇脂联素浓度明显高于剖宫产组，这可能是由于分娩过程中母体脂联素释放增加所致。
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