体力活动和运动干预对囊性纤维化患者身体健康影响的系统评价方案。

The impact of physical activity and exercise interventions for physical health in people with cystic fibrosis: protocol for a systematic review.

机构信息

Children's Health and Exercise Research Centre, Sport and Health Sciences, University of Exeter, Heavitree Road, Exeter, EX1 2LU, UK.

Royal Devon and Exeter NHS Foundation Trust Hospital, Barrack Road, Exeter, EX2 5DW, UK.

出版信息

Syst Rev. 2021 Feb 26;10(1):64. doi: 10.1186/s13643-021-01614-8.

DOI:10.1186/s13643-021-01614-8

PMID:33637136

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7913325/

Abstract

BACKGROUND

Cystic fibrosis (CF) is a genetically inherited, life-limiting condition, affecting ~90,000 people globally. Physical activity (PA) and exercise form an integral component of CF management, and have been highlighted by the CF community as an area of interest for future research. Previous reviews have solely focused on PA or structured exercise regimens independent of one another, and thus a comprehensive assessment of the physical health benefits of all PA, including exercise, interventions, is subsequently warranted. Therefore, the purpose of this review is to evaluate the effects of both PA and exercise upon outcomes of physical health and healthcare utilisation in people with CF.

METHODS

A systematic review has been registered and reported in line with Preferred Reporting Items for Systematic Reviews and Meta-Analysis-P guidelines. This will include randomised control trials on the effects of PA and exercise, relative to usual treatment, upon people with CF. Primary outcomes will include variables associated with fitness, PA, lung health, inflammation, body composition, glycaemic control and patient-reported outcomes. Secondary outcomes will include adverse events and healthcare utilisation. Searches will be undertaken in Ovid MEDLINE, OVID EMBASE, PsychINFO, ERIC, SPORTDiscus, ASSIA, CCTR, CINHAL and Web of Science databases, and will be searched from date of inception onwards. Two reviewers will independently screen citations and abstracts, and full-texts, for inclusion and data extraction, respectively. Methodological quality will be assessed using the Cochrane Risk of Bias-2 tool. If feasible, random-effects meta-analyses will be conducted where appropriate. Additional analyses will explore potential sources of heterogeneity, such as age, sex, and disease severity.

DISCUSSION

This systematic review will build on previous research, by comprehensively assessing the impact of both PA and exercise upon physical health and healthcare utilisation in people with CF. Results of this review will be utilised to inform discussions that will ultimately result in a consensus document on the impact of physical activity and exercise for people with CF.

SYSTEMATIC REVIEW REGISTRATION

PROSPERO CRD42020184411.

摘要

背景

囊性纤维化（CF）是一种遗传性、限制生命的疾病，影响全球约 9 万人。身体活动（PA）和运动是 CF 管理的一个组成部分，已经被 CF 社区强调为未来研究的一个感兴趣的领域。以前的综述仅侧重于 PA 或独立于彼此的结构化运动方案，因此，有必要对所有 PA（包括运动）的身体健康益处进行全面评估，包括干预措施。因此，本综述的目的是评估 PA 和运动对 CF 患者身体健康和医疗保健利用结果的影响。

方法

已对系统评价进行了注册，并按照系统评价和荟萃分析优先报告项目的建议进行了报告。这将包括关于 PA 和运动对 CF 患者的影响的随机对照试验，相对于常规治疗。主要结果将包括与健康相关的变量、PA、肺健康、炎症、身体成分、血糖控制和患者报告的结果。次要结果将包括不良事件和医疗保健利用。将在 Ovid MEDLINE、Ovid EMBASE、PsychINFO、ERIC、SPORTDiscus、ASSIA、CCTR、CINHAL 和 Web of Science 数据库中进行搜索，并从成立之日起进行搜索。两名审查员将分别独立筛选引文和摘要，并分别进行全文筛选和数据提取。使用 Cochrane 风险偏倚-2 工具评估方法学质量。如果可行，将在适当情况下进行随机效应荟萃分析。额外的分析将探索潜在的异质性来源，如年龄、性别和疾病严重程度。