Universidad de Cantabria Facultad de Medicina, Santander, Cantabria, Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
BMJ Open. 2021 Feb 26;11(2):e044224. doi: 10.1136/bmjopen-2020-044224.
The Mother and Child COVID-19 study is a cohort recruiting pregnant women and their children in Cantabria, North of Spain, during COVID-19 pandemic in order to ascertain consequences of SARS-CoV-2 infection on pregnant women and their descendants. This article reports the cohort profile and preliminary results as recruitment is still open.
Three subcohorts can be identified at recruitment. Subcohort 1 includes women giving birth between 23 March and 25 May 2020; they have been retrospectively recruited and could have been exposed to COVID-19 only in their third trimester of pregnancy. Subcohort 2 includes women giving birth from 26 May 2020 on; they are being prospectively recruited and could have been exposed to COVID-19 in both their second and third trimesters of pregnancy. Subcohort 3 includes women in their 12 week of pregnancy prospectively recruited from 26 May 2020 on; they could have been exposed to COVID-19 anytime in their pregnancy. All women are being tested for SARS-CoV-2 infection using both RT-PCR for RNA detection and ELISA for anti-SARS-CoV-2 antibodies. All neonates are being tested for antibodies using immunochemoluminiscency tests; if the mother is tested positive for SARS-CoV-2 RNA, a nasopharyngeal swab is also obtained from the child for RT-PCR analysis.
As of 22 October, 1167 women have been recruited (266, 354 and 547 for subcohorts 1, 2 and 3, respectively). Fourteen women tested positive to SARS-CoV-2 RNA by the day of delivery. All 14 children born from these women tested negative for SARS-CoV-2 RNA.
Children from women included in subcohort 3 are expected to be recruited by the end of 2020. Children will be followed-up for 1 year in order to ascertain the effect that COVID-19 on their development.
“母婴 COVID-19 研究”是一项在西班牙北部坎塔布里亚招募孕妇及其子女的队列研究，旨在确定 SARS-CoV-2 感染对孕妇及其后代的影响。本文报告了该队列的特征和初步结果，因为招募仍在进行中。
在招募时可以确定三个亚组。亚组 1 包括在 2020 年 3 月 23 日至 5 月 25 日之间分娩的女性；她们是回顾性招募的，仅在妊娠晚期可能接触过 COVID-19。亚组 2 包括从 2020 年 5 月 26 日开始分娩的女性；她们正在前瞻性招募，可能在妊娠第二和第三阶段接触过 COVID-19。亚组 3 包括从 2020 年 5 月 26 日开始前瞻性招募的处于妊娠 12 周的女性；她们在妊娠期间任何时候都可能接触过 COVID-19。所有女性均采用 RT-PCR 检测 RNA 和 ELISA 检测抗 SARS-CoV-2 抗体来检测 SARS-CoV-2 感染。所有新生儿均采用免疫化学发光试验检测抗体；如果母亲的 SARS-CoV-2 RNA 检测呈阳性，还从儿童中获取鼻咽拭子进行 RT-PCR 分析。
截至 2020 年 10 月 22 日，已招募了 1167 名女性（亚组 1、2 和 3 分别为 266、354 和 547 名）。在分娩当天，有 14 名女性的 SARS-CoV-2 RNA 检测呈阳性。所有来自这些女性的 14 名儿童的 SARS-CoV-2 RNA 检测均为阴性。
预计到 2020 年底将招募亚组 3 中的女性的儿童。将对儿童进行为期 1 年的随访，以确定 COVID-19 对其发育的影响。
