Akbarian-Rad Zahra, Mojaveri Mohsen Haghshenas, Bouzari Zinatossadat, Sadeghi Farzin, Yahyapour Yousef, Rad Mojgan Naeimi, Alizadeh Somayeh, Ebrahimpour Soheil, Sepidarkish Mahdi, Javanian Mostafa
Non-Communicable Pediatric Disease Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Department of Obstetrics & Gynecology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
Infect Dis Obstet Gynecol. 2021 Jun 2;2021:9952701. doi: 10.1155/2021/9952701. eCollection 2021.
During the coronavirus disease 2019 (COVID-19) pandemic, the number of pregnant women and neonates suffering from COVID-19 increased. However, there is a lack of evidence on clinical characteristics and neonatal outcomes in pregnant women with COVID-19. We evaluated short-term outcomes (4 weeks postdischarge) and symptoms in neonates born to mothers infected with COVID-19. In this retrospective cohort study, we included all neonates born to pregnant women with COVID-19 admitted to Ayatollah Rohani Hospital, Babol, Iran, from February 10 to May 20, 2020. Clinical features, treatments, and neonatal outcomes were measured. Eight neonates were included in the current study. The mean gestational age and birth weight of newborns were 37 ± 3.19 weeks (30-40) and 3077.50 ± 697.64 gr (1720-3900), respectively. Apgar score of the first and fifth minutes in all neonates was ≥8 and ≥9 out of 10, respectively. The most clinical presentations in symptomatic neonates were respiratory distress, tachypnea, vomiting, and feeding intolerance. This manifestation and high levels of serum C-reactive protein (CRP) in three infants are common in neonatal sepsis. The blood culture in all of them was negative. They have been successfully treated with our standard treatment. Our pregnant women showed a pattern of clinical characteristics and laboratory results similar to those described for nonpregnant COVID-19 infection. This study found no evidence of intrauterine or peripartum transmission of COVID-19 from mother to her child. Furthermore, the long-term outcomes of neonates need more study.
在2019年冠状病毒病（COVID-19）大流行期间，感染COVID-19的孕妇和新生儿数量有所增加。然而，目前缺乏关于感染COVID-19孕妇的临床特征和新生儿结局的证据。我们评估了感染COVID-19母亲所生新生儿的短期结局（出院后4周）和症状。在这项回顾性队列研究中，我们纳入了2020年2月10日至5月20日在伊朗巴博勒阿亚图拉·罗哈尼医院住院的所有感染COVID-19孕妇所生的新生儿。对临床特征、治疗方法和新生儿结局进行了测量。本研究共纳入8例新生儿。新生儿的平均胎龄和出生体重分别为37±3.19周（30 - 40周）和3077.50±697.64克（1720 - 3900克）。所有新生儿出生后第1分钟和第5分钟的阿氏评分分别≥8分和≥9分（满分10分）。有症状新生儿最常见的临床表现为呼吸窘迫、呼吸急促、呕吐和喂养不耐受。这种表现以及3例婴儿血清C反应蛋白（CRP）水平升高在新生儿败血症中较为常见。他们所有人的血培养均为阴性。他们已通过我们的标准治疗成功治愈。我们的孕妇表现出的临床特征和实验室检查结果模式与非孕妇COVID-19感染所描述的相似。本研究未发现COVID-19从母亲垂直传播至其子女的宫内或围产期传播证据。此外，新生儿的长期结局还需要更多研究。
