Patnaik A K, Mooney S
Department of Pathology, Animal Medical Center, New York, NY.
Vet Pathol. 1988 Mar;25(2):105-12. doi: 10.1177/030098588802500201.
Melanomas diagnosed in 29 cats over an 11 year period included 19 ocular (16 intraocular, three palpebral), five oral, and five dermal melanomas. Intraocular melanomas involved the ciliary body and iris in 12; the whole eye was involved in four. The average age of cats with intraocular melanomas was 11 years; the female : male ratio was 9 : 7. Histologically, eight intraocular tumors were mixed, six were epithelioid, and two were spindle cell. Ten of 16 cats (62.5%) with intraocular melanomas were killed because of the tumor at a mean of 156 days; four are living with no evidence of disease (average, 255 days). The mean time of death in cats with palpebral melanoma was 409 days. Metastasis occurred in 63% of cats with intraocular melanoma and all cats with palpebral melanoma. Four cats with oral melanoma were killed at a mean of 61 days; all had metastasis. Of five cats with cutaneous melanoma, one was killed with metastasis at 90 days; three cats were alive without evidence of recurrence or metastasis greater than 365 days after surgery. Results of this study indicate that in the cat, ocular melanomas are more common than oral and dermal melanomas, and ocular and oral melanomas are more malignant than dermal melanomas, with higher rates of mortality and metastasis.
在11年期间诊断出的29例猫黑色素瘤中，包括19例眼部黑色素瘤（16例眼内黑色素瘤，3例睑部黑色素瘤）、5例口腔黑色素瘤和5例皮肤黑色素瘤。12例眼内黑色素瘤累及睫状体和虹膜；4例累及全眼。眼内黑色素瘤猫的平均年龄为11岁；雌雄比例为9:7。组织学上，8例眼内肿瘤为混合型，6例为上皮样型，2例为梭形细胞型。16例眼内黑色素瘤猫中有10例（62.5%）因肿瘤死亡，平均存活156天；4例存活且无疾病证据（平均255天）。睑部黑色素瘤猫的平均死亡时间为409天。63%的眼内黑色素瘤猫和所有睑部黑色素瘤猫发生转移。4例口腔黑色素瘤猫平均在61天时死亡；均发生转移。5例皮肤黑色素瘤猫中，1例在90天时因转移死亡；3例在术后365天以上存活，无复发或转移证据。本研究结果表明，在猫中，眼部黑色素瘤比口腔和皮肤黑色素瘤更常见，且眼部和口腔黑色素瘤比皮肤黑色素瘤更具恶性，死亡率和转移率更高。
