Everitt J I, Olson L M, Mangum J B, Visek W J
Department of Pathobiology, School of Veterinary Medicine, University of Illinois, Urbana.
Vet Pathol. 1988 Mar;25(2):113-8. doi: 10.1177/030098588802500202.
Severe degenerative myocardial disease occurred in female C3H/OUJ mice fed purified diets for 36 weeks; the diet contained 5% or 20% fat as non-hydrogenated soybean oil. Deaths of lactating females of this group (17/35 high fat diet and 7/35 low fat diet animals) were due to sudden cardiovascular collapse. Cardiomegaly with marked atrial and ventricular myocardial mineralization was seen at necropsy. Histologically, the random, myopathic foci were characterized by severe myocardial degeneration, mineralization, and fibrosis. Mural thrombosis, pulmonary arteriosclerosis, and mild myocardial inflammatory cell infiltrates were also present. Pathological changes were similar to those of dystrophic cardiac calcinosis, an incidental necropsy finding in certain mouse strains.
给雌性C3H/OUJ小鼠喂食纯化饮食36周后出现严重的退行性心肌病；该饮食含有5%或20%的脂肪，以非氢化大豆油形式存在。该组哺乳期雌性小鼠（高脂肪饮食组35只中有17只，低脂肪饮食组35只中有7只）死亡原因是心血管突然衰竭。尸检时可见心脏肿大，伴有明显的心房和心室心肌矿化。组织学上，随机出现的肌病病灶的特征为严重的心肌变性、矿化和纤维化。还存在壁层血栓形成、肺动脉硬化和轻度心肌炎性细胞浸润。病理变化与营养不良性心脏钙化相似，后者是某些小鼠品系尸检时偶然发现的情况。
