College of Life Sciences, Shandong Agricultural University, Tai'an 271018, People's Republic of China.
Int J Med Mushrooms. 2021;23(2):85-96. doi: 10.1615/IntJMedMushrooms.2021037648.
The present work was designed to investigate the antioxidant and hepatoprotective effects of acidic-hydrolysis Lentinus edodes residue polysaccharides (Ac-LRP) on lipopolysaccharide-induced liver injury in mice. Hepatoprotective effects were observed in liver treated with Ac-LRP at doses of 200, 400, and 600 mg/kg body weight, respectively. Activities of superoxide dismutase, glutathione peroxide, catalase, total antioxidant capacity, alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase and levels of total cholesterol, triglyceride, malondialdehyde, and lipid peroxidation in liver or serum samples were analyzed. Ac-LRP reduced the incidence of liver necrosis detected via histological observations. In addition, Ac-LRP chemical bonds and ultrastructure were measured. These results provided valuable evidence supporting the utilization of Ac-LRP as a functional food and natural medicine for the treatment of liver injury.
本研究旨在探讨酸性水解香菇残渣多糖（Ac-LRP）对脂多糖诱导的小鼠肝损伤的抗氧化和保肝作用。结果表明，在 200、400 和 600 mg/kg 体重剂量下，Ac-LRP 对肝脏具有保护作用。分别对各剂量组肝组织中超氧化物歧化酶、谷胱甘肽过氧化物酶、过氧化氢酶、总抗氧化能力、丙氨酸氨基转移酶、天冬氨酸氨基转移酶和碱性磷酸酶的活性以及血清和肝组织中总胆固醇、甘油三酯、丙二醛和脂质过氧化水平进行分析。结果表明，Ac-LRP 降低了肝组织坏死的发生率。此外，还对 Ac-LRP 的化学结构和超微结构进行了测定。这些结果为将 Ac-LRP 作为功能性食品和天然药物用于治疗肝损伤提供了有价值的证据。
