Key Laboratory of Ministry of Education for Medicinal Resource and Natural Pharmaceutical Chemistry, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, China.
Food Chem. 2013 Dec 15;141(4):3415-23. doi: 10.1016/j.foodchem.2013.06.058. Epub 2013 Jun 22.
This study was to examine the hepatoprotective effects of polysaccharides from green tea of Huangshan Maofeng (HMTP) against CCl4-induced oxidative damage in mice. HMTP is an acidic heteropolysaccharide with galactose (35.0%, mol.%), arabinose (28.9%) and galacturonic acid (11.3%) being the main monosaccharide components. HMTP (400 and 800 mg/kg·bw) administered orally daily for 14 days before CCl4 administration significantly reduced the impact of CCl4 toxicity on the serum markers of liver damage, alanine aminotransferase, aspartate aminotransferase, total-cholesterol and triglycerides. This method of HMTP administration also markedly restrained hepatic lipid peroxidation formation of malondialdehyde and 15-F2t isoprostanes, and elevated the antioxidant levels of hepatic glutathione and superoxide dismutase. These results together with liver histopathology indicated that HMTP exhibited hepatoprotection against CCl4-induced injury, which was found to be comparable to that of biphenyldicarboxylate. The hepatoprotective effects of HMTP may be due to both the inhibition of lipid peroxidation and the increase of antioxidant activity.
本研究旨在探讨黄山毛峰茶多糖（HMTP）对 CCl4 诱导的小鼠氧化损伤的肝保护作用。HMTP 是一种酸性杂多糖，主要单糖组分为半乳糖（35.0%，mol.）、阿拉伯糖（28.9%）和半乳糖醛酸（11.3%）。HMTP（400 和 800mg/kg·bw）每天口服给药，在给予 CCl4 前连续 14 天，可显著降低 CCl4 毒性对血清肝损伤标志物、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、总胆固醇和甘油三酯的影响。这种 HMTP 给药方式还显著抑制了肝脂质过氧化丙二醛和 15-F2t 异前列腺素的形成，并提高了肝谷胱甘肽和超氧化物歧化酶的抗氧化水平。这些结果与肝组织病理学一起表明，HMTP 对 CCl4 诱导的损伤具有肝保护作用，其作用与联苯二甲酸二酯相当。HMTP 的肝保护作用可能归因于抑制脂质过氧化和增加抗氧化活性。
