Da Volterra, Paris, France; Université de Paris, IAME, INSERM, Paris, France.
Da Volterra, Paris, France.
Drug Discov Today. 2021 Sep;26(9):2159-2163. doi: 10.1016/j.drudis.2021.02.022. Epub 2021 Feb 25.
Homeostasis of the intestinal microbiota is currently recognized as a major contributor to human health. Furthermore, intestinal dysbiosis is associated with a multitude of consequences, including intestinal colonization by antibiotic-resistant or pathogenic bacteria, such as Clostridioides difficile, and reduced efficacy of promising anticancer immunotherapies. By far, the most immediate and drastic exposure leading to dysbiosis is antibiotic treatment. Many attempts have been made to prevent or repair antibiotic-associated dysbiosis. Here, we review these innovations and the difficulties associated with their development.
目前，人们认为肠道微生物组的稳态是人类健康的主要贡献者。此外，肠道菌群失调与多种后果相关，包括对抗生素耐药或致病细菌（如艰难梭菌）的肠道定植，以及有前途的癌症免疫疗法的疗效降低。到目前为止，导致菌群失调的最直接和最剧烈的暴露是抗生素治疗。人们已经尝试了许多方法来预防或修复与抗生素相关的菌群失调。在这里，我们回顾了这些创新以及它们发展所面临的困难。
