Department of Hepatobiliary Surgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, School of Clinical Medicine, Henan University, Zhengzhou 450003, Henan, China.
Aging (Albany NY). 2021 Feb 26;13(5):7133-7146. doi: 10.18632/aging.202570.
The aim of this study was to evaluate the clinical features and prognostic factors of elderly patients with metastatic pancreatic cancer. Patients diagnosed with metastatic pancreatic cancer between 2004 and 2014 were identified from the Surveillance Epidemiology and End Results database. Clinical characteristics and prognostic factors in elderly patients with metastatic pancreatic cancer were examined. A total of 10784 metastatic pancreatic cancer patients between 65 and 80 years old were included and divided into three age groups. Elderly metastatic pancreatic cancer patients differed from younger patients in many aspects, including marital status, race, sex, T stage, N stage, treatment regimen, prognosis, cause of death, and metastatic characteristics (P<0.001). An analysis of prognostic factors showed that chemotherapy, as the main treatment for elderly patients, can significantly improve prognosis, while surgery can improve the prognosis of patients between 65 and 80 years old. Other factors, including sex, marital status, T stage, and site of metastasis, had different effects on patients in different age groups. Elderly patients with metastatic pancreatic cancer are a special group of individuals whose clinical characteristics and prognostic factors are different from those of younger patients, and these patients require special treatment and attention.
本研究旨在评估老年转移性胰腺癌患者的临床特征和预后因素。从监测、流行病学和最终结果（SEER）数据库中确定了 2004 年至 2014 年间诊断为转移性胰腺癌的患者。检查了老年转移性胰腺癌患者的临床特征和预后因素。共纳入 10784 例 65-80 岁的转移性胰腺癌患者，并分为三组。老年转移性胰腺癌患者在许多方面与年轻患者不同，包括婚姻状况、种族、性别、T 分期、N 分期、治疗方案、预后、死亡原因和转移特征（P<0.001）。预后因素分析表明，化疗是老年患者的主要治疗方法，可显著改善预后，而手术可改善 65-80 岁患者的预后。其他因素，包括性别、婚姻状况、T 分期和转移部位，对不同年龄组的患者有不同的影响。老年转移性胰腺癌患者是一个特殊的群体，其临床特征和预后因素与年轻患者不同，需要特殊的治疗和关注。
