Department of Nephrology, Henan Provincial People's Hospital, Henan Provincial Key Laboratory of Kidney Disease and Immunology, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou 450003, Henan, China.
Department of Hepatobiliary Surgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan University Peoples Hospital, Zhengzhou 450003, Henan, China.
Aging (Albany NY). 2021 Mar 3;13(6):8290-8305. doi: 10.18632/aging.202637.
This study compared the clinicopathological characteristics and survival of patients with metastatic renal cell carcinoma (mRCC) stratified by age to identify clinical features and prognostic factors. Patients with renal cell carcinoma (RCC) between 2010 and 2015 were identified from the Surveillance, Epidemiology and End Results database. Age was an independent prognostic factor for patients with RCC, mRCC, mRCC of clear cell renal cell carcinoma and lung-related metastases. There were many significant differences between the younger and older groups, including differences in marital status, race, sex, year of diagnosis, histology grade, laterality, T stage, N stage, tumor size, type of treatment, including surgery, radiation or chemotherapy, and pattern of organic metastasis to the liver, lung, or brain (P<0.05). Moreover, different natural metastasis patterns and poorer overall survival were observed in the older group compared with the younger group (P<0.05). Parameters, including marital status, sex, year of diagnosis, histological grade, N stage, surgery, chemotherapy, lung metastasis and liver metastasis, were independent prognostic factors for elderly patients (P<0.05). Age plays a significant role in mRCC, and elderly patients with mRCC are a special group of individuals whose clinical characteristics and prognostic factors are different from those of younger patients; therefore, these patients require special attention.
本研究通过对年龄分层的转移性肾细胞癌（mRCC）患者的临床病理特征和生存情况进行比较，以确定临床特征和预后因素。从监测、流行病学和最终结果数据库中确定了 2010 年至 2015 年期间患有肾细胞癌（RCC）的患者。年龄是 RCC、mRCC、透明细胞肾细胞癌 mRCC 和与肺相关的转移患者的独立预后因素。年轻组和老年组之间存在许多显著差异，包括婚姻状况、种族、性别、诊断年份、组织学分级、侧别、T 分期、N 分期、肿瘤大小、治疗类型（包括手术、放疗或化疗）以及肝、肺或脑的有机转移模式（P<0.05）。此外，与年轻组相比，老年组的自然转移模式不同，总体生存率较差（P<0.05）。婚姻状况、性别、诊断年份、组织学分级、N 分期、手术、化疗、肺转移和肝转移是老年患者的独立预后因素（P<0.05）。年龄在 mRCC 中起着重要作用，老年 mRCC 患者是一个特殊的群体，其临床特征和预后因素与年轻患者不同；因此，这些患者需要特别关注。
