Department of Nephrology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China.
The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China.
Aging (Albany NY). 2021 Feb 26;13(5):6904-6917. doi: 10.18632/aging.202548.
We investigated how age affected renal function in healthy subjects in Beijing and compared different estimated glomerular filtration rate (eGFR) equations. Kidney function was evaluated by five equations: Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI); Modification of Diet in Renal Disease Study (MDRD); the Chinese version of the MDRD (MDRDc); Full Age Spectrum (FAS); and Berlin Initiative Study (BIS). A total of 46,708 subjects were enrolled and followed-up for 3 years. All showed an increase in sCr and a reduction in eGFR with increasing age. Over the 3 years, the eGFR and serum creatinine (sCr) remained unchanged in most subjects. Different equations showed good consistency; the intraclass correlation coefficients (ICC) was 0.849 for males, and 0.817 for females. The CKD-EPI equation yielded higher GFR values than the other equations (according to sCr levels). For subjects aged over 70 years, the BIS equation produced the lowest eGFR values. In summary, we observed that the renal function of individuals was relatively stable with increasing age, although different eGFR equations yielded data that varied across different populations of subjects and sCr levels.
我们研究了年龄对北京健康受试者肾功能的影响，并比较了不同的估算肾小球滤过率（eGFR）方程。通过五个方程评估肾脏功能：慢性肾脏病流行病学合作研究（CKD-EPI）；肾脏病饮食改良研究（MDRD）；MDRD 的中文版（MDRDc）；全年龄谱（FAS）；和柏林倡议研究（BIS）。共纳入 46708 例受试者并随访 3 年。所有受试者的 sCr 均升高，eGFR 随年龄增长而降低。在 3 年内，大多数受试者的 eGFR 和血清肌酐（sCr）保持不变。不同的方程表现出良好的一致性；男性的组内相关系数（ICC）为 0.849，女性为 0.817。与其他方程相比，CKD-EPI 方程得出的 GFR 值更高（根据 sCr 水平）。对于年龄超过 70 岁的受试者，BIS 方程得出的 eGFR 值最低。总之，我们观察到个体的肾功能随年龄增长而相对稳定，尽管不同的 eGFR 方程得出的数据因不同的受试者人群和 sCr 水平而异。
