Department of Oral Pathology, Maulana Azad Institute of Dental Sciences, India.
Asian Pac J Cancer Prev. 2021 Feb 1;22(2):341-347. doi: 10.31557/APJCP.2021.22.2.341.
Backgroud: In the microenvironment of Oral Squamous Cell Carcinoma (OSCC), Hypoxia-inducible transcription factor 1 (HIF-1) is a very important chemical mediator in the microenvironment of OSCC through which cells respond to hypoxia. LOXL-2 participates in ECM remodelling, and also in regulating epithelial-to-mesenchymal transition, epithelial cell polarity and differentiation. Aim/material and methods: The present study was conducted on 90 histopathologically proven cases of OSCC to ascertain the role of HIF-1α and LOXL-2 in OSCC. Immunoexpression of both HIF-1α and LOXL-2 was analyzed both quantitatively and qualitatively and compared with tumor stage, nodal stage, clinical stage, and histological grade. Results: Tumor stages and nodal stages had significant correlation with HIF-1α expression and localization of LOXL-2 immunoexpression respectively. Conclusion: This is probably the first study to analyze LOXL-2 localization in OSCC. Alteration in the immunoexpression of LOXL-2 from nuclear to cytoplasmic and HIF-1α immunoexpression might be an important factor in progression of OSCC.
在口腔鳞状细胞癌（OSCC）的微环境中，缺氧诱导因子 1（HIF-1）是 OSCC 微环境中一种非常重要的化学介质，通过它细胞对缺氧作出反应。LOXL-2 参与细胞外基质重塑，并调节上皮间质转化、上皮细胞极性和分化。目的/材料和方法：本研究对 90 例经组织病理学证实的 OSCC 病例进行了研究，以确定 HIF-1α 和 LOXL-2 在 OSCC 中的作用。对 HIF-1α 和 LOXL-2 的免疫表达进行了定量和定性分析，并与肿瘤分期、淋巴结分期、临床分期和组织学分级进行了比较。结果：肿瘤分期和淋巴结分期与 HIF-1α 表达和 LOXL-2 免疫表达的定位分别有显著相关性。结论：这可能是首次分析 LOXL-2 在 OSCC 中的定位的研究。LOXL-2 免疫表达从核到细胞质的改变和 HIF-1α 免疫表达可能是 OSCC 进展的一个重要因素。
