Sørensen P S, Krogsaa B, Gjerris F
University Department of Neurology, Rigshospitalet, Copenhagen, Denmark.
Acta Neurol Scand. 1988 Feb;77(2):164-72. doi: 10.1111/j.1600-0404.1988.tb05888.x.
In a prospective study, 24 consecutive patients with pseudotumor cerebri were followed for an average of 49 months with regular neurologic and ophthalmologic examinations. At the first examination the intracranial pressure was between 18 and 45 mm Hg; several patients had pressure waves up to 70 mm Hg and decreased conductance to cerebrospinal fluid outflow. In the majority, medical treatment, usually with diuretics and acetazolamide, induced a rapid relief of symptoms, but about 25% had a more protracted disease course with persistent headache, asthenia and memory disturbances interfering with daily life. Five patients required a shunt operation. Chronic changes of the optic disc developed in nearly half the patients, and one had optic atrophy and severe visual impairment. Repeated measurements of the intracranial pressure and conductance to cerebrospinal fluid outflow showed that abnormalities can persist for a long time, even in cases without symptoms of intracranial hypertension.
在一项前瞻性研究中，对24例连续的假性脑瘤患者进行了平均49个月的随访，定期进行神经学和眼科检查。首次检查时，颅内压在18至45毫米汞柱之间；数名患者的压力波高达70毫米汞柱，脑脊液流出传导性降低。大多数患者通过通常使用利尿剂和乙酰唑胺的药物治疗，症状迅速缓解，但约25%的患者病程迁延，持续存在头痛、乏力和记忆障碍，影响日常生活。5例患者需要进行分流手术。近半数患者出现视盘慢性改变，1例出现视神经萎缩和严重视力损害。对颅内压和脑脊液流出传导性的反复测量表明，即使在没有颅内高压症状的情况下，异常情况也可能长期存在。
