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研究主动病例发现(ACF)对南德里发现的结核患者的影响。

To study the impact of active case finding (ACF) among the TB patients detected in South Delhi.

机构信息

Department of Respiratory Medicine, National Institute of TB and Respiratory Diseases, New Delhi, India.

Department of Respiratory Medicine, National Institute of TB and Respiratory Diseases, New Delhi, India.

出版信息

Indian J Tuberc. 2021 Jan;68(1):80-84. doi: 10.1016/j.ijtb.2020.08.011. Epub 2020 Aug 26.

Abstract

BACKGROUND

TB is one of the top 10 causes of death worldwide. The WHO adopted the End TB Strategy with ambitious goal of ending the global TB epidemic by 2030. The targets for this were 95% reduction in number of TB deaths, 90% reduction in TB incidence rate between 2015 and 2035 and to ensure that no family is burdened with catastrophic expenditure due to TB. Enhanced case detection is one of the components of End TB strategy adopted by WHO and within this Active Case Finding has an important place. However, its role in the Indian context needs to be assessed.

AIMS AND OBJECTIVES

To study the impact of Active Case Finding (ACF) in National Tuberculosis Elimination Program (NTEP) implementing area of National Institute of TB and Respiratory Diseases New Delhi in terms of case detection and treatment outcome.

MATERIALS AND METHODS

The TB patients detected during ACF through house to house survey in vulnerable population were identified, evaluated and followed up. Data from ACF records and TB treatment cards were filled in a pretested proforma and compared with passive case detection in the previous month from same area.

RESULTS

In December 2017 a total 8600 vulnerable population (living in slums, camps and night shelters) were screened over two weeks of whom 85 were found to have symptoms suggestive of TB of whom 19 were PTB that gives a case detection rate of 220 per lakh population. PTB case detection rate by passive case finding (PCF) in November 2017 from the same area of our study was found to be 63 per lakh population. This difference between the detection rate in ACF and passive case findings was statistically significant with Z proportion test and p value <0.00001. Treatment success rate was 75% and lost to follow up rate was 25% patients among the PTB patients detected in ACF. In passive case detection from the same area in November 2017 treatment success rate was 81.8% and lost to follow up rate (LTFU) was 18% in PTB patients. Even though LTFU rate was slightly higher but was not statistically significant.

CONCLUSION

ACF is an effective way to find additional cases of TB. ACF is more labour intensive than PCF but if judiciously used under national programme to target specific vulnerable population of society it can produce additional number of TB cases which otherwise would have gone undiagnosed. However, treatment outcome for these patients is below the target and hence to get the maximum impact of ACF there is a need to enhance the adherence to treatment through different methodologies. Poor treatment adherence will lead to increase transmission risk in communities and greater chance of developing drug resistance. Further studies with larger representative population should be undertaken in order to get more conclusive.

摘要

背景

结核病是全球十大死因之一。世界卫生组织(WHO)通过了终结结核病策略,该策略设定了到 2030 年终结全球结核病流行的宏伟目标,包括结核病死亡率降低 95%,2015 年至 2035 年期间结核病发病率降低 90%,确保没有家庭因结核病而陷入灾难性支出。强化病例发现是世界卫生组织采用的终结结核病策略的组成部分之一,在该策略中,主动病例发现(ACF)占有重要地位。然而,它在印度的作用需要进行评估。

目的和目标

评估在国家结核病和呼吸疾病研究所新德里国家结核病消除规划(NTEP)实施地区,主动病例发现(ACF)对病例检出和治疗结局的影响。

材料和方法

通过对弱势人群进行逐户调查发现并评估结核病患者,并对其进行随访。从 ACF 记录和结核病治疗卡中获取数据,填写预测试表格,并与前一个月来自同一地区的被动病例发现进行比较。

结果

2017 年 12 月,在两周的时间里对 8600 名弱势人群(居住在贫民窟、营地和夜间收容所)进行了筛查,其中 85 人出现疑似结核病症状,其中 19 人患有肺结核,每 10 万人的检出率为 220 例。2017 年 11 月,来自同一研究地区的被动病例发现(PCF)发现肺结核患者的检出率为每 10 万人 63 例。ACF 和被动病例发现之间的检出率差异具有统计学意义,Z 比例检验和 p 值<0.00001。在 ACF 中发现的肺结核患者中,治疗成功率为 75%,失访率为 25%。在 2017 年 11 月来自同一地区的被动病例发现中,肺结核患者的治疗成功率为 81.8%,失访率(LTFU)为 18%。尽管失访率略高,但无统计学意义。

结论

ACF 是发现结核病的有效方法。与 PCF 相比,ACF 更耗费人力,但如果在国家规划下明智地针对社会特定的弱势人群使用,它可以发现更多的结核病病例,否则这些病例将无法被诊断。然而,这些患者的治疗结局低于目标,因此,要想使 ACF 产生最大影响,需要通过不同的方法来提高治疗的依从性。较差的治疗依从性会导致社区传播风险增加,产生耐药性的几率增加。需要进一步开展具有更大代表性人群的研究,以获得更具结论性的结果。

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