Students Research Committee, Arak University of Medical Sciences, Arak, Iran.
Department of Anesthesiology and Critical Care, Arak University of Medical Sciences, Arak, Iran.
Med Gas Res. 2021 Jan-Mar;11(1):1-5. doi: 10.4103/2045-9912.310052.
Physiological responses remain common during anesthesia emergence and endotracheal extubation, causing some complications. We aimed to address the effect of dexmedetomidine (DEX) on decrease of cough, hemodynamic parameters and Ramsay score in comparing to lidocaine (LID) during anesthesia. In this double-blinded randomized clinical trial 120 hospitalized patients undergoing general anesthesia were enrolled after obtaining written consent. Block random allocation was used to assign patients into three groups including DEX (intravenous injection; 0.5 μg/kg), LID (1.5 mg/kg), and PBO (10 mL normal saline) at 10 minutes before anesthesia. No statistical significance was uncovered among three groups in blood pressure, oxygen saturation, frequency of laryngospasm and duration of surgery amongst the groups (P > 0.05), but DEX having lower heart rate and cough frequency (P < 0.05). Moreover, the mean of Ramsay score was statistically higher in DEX and LID groups than PBO except at the 50 and 60 minutes after extubation (P < 0.05). Since the mean of Ramsay score was higher in DEX vs. LID groups and reduced heart rate and cough frequency demonstrates in DEX, it seems that DEX could be an appropriate drug on suppressing cough during anesthesia without side effects. The study protocol was approved by the Ethical Committee of Arak University of Medical Sciences by code IR.ARAKMU.REC.1397.140 on August 19, 2018, and the protocol was registered at Iranian Registry of Clinical Trials by code IRCT20141209020258N97 on February 22, 2019.
在麻醉苏醒和气管拔管期间，生理反应仍然很常见，导致一些并发症。我们旨在研究右美托咪定（DEX）与利多卡因（LID）相比，在降低麻醉期间咳嗽、血液动力学参数和 Ramsay 评分方面的效果。
在这项双盲随机临床试验中，我们纳入了 120 名接受全身麻醉的住院患者，并在获得书面同意后进行研究。采用区组随机化方法将患者分为三组，分别为 DEX（静脉注射；0.5μg/kg）、LID（1.5mg/kg）和 PBO（10mL 生理盐水），在麻醉前 10 分钟给药。
三组之间的血压、氧饱和度、喉痉挛的发生频率和手术持续时间无统计学差异（P>0.05），但 DEX 组的心率和咳嗽频率较低（P<0.05）。此外，DEX 和 LID 组的 Ramsay 评分均值高于 PBO 组，但在拔管后 50 分钟和 60 分钟时除外（P<0.05）。
由于 DEX 组的 Ramsay 评分均值高于 LID 组，DEX 组的心率和咳嗽频率降低，因此，DEX 似乎是一种在麻醉期间抑制咳嗽的合适药物，且无副作用。研究方案于 2018 年 8 月 19 日经阿拉克医科大学伦理委员会批准（注册号 IR.ARAKMU.REC.1397.140），并于 2019 年 2 月 22 日在伊朗临床试验注册中心注册（注册号 IRCT20141209020258N97）。
