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How would preclinical Alzheimer's disease (AD pathology) occur? An insight from a genomic instability mouse model.

作者信息

Rao Chinthalapally V, Yamada Hiroshi Y

机构信息

Center for Cancer Prevention and Drug Development, Department of Medicine, Hematology/Oncology Section, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA.

出版信息

Neural Regen Res. 2021 Oct;16(10):2012-2014. doi: 10.4103/1673-5374.308096.

DOI:10.4103/1673-5374.308096
PMID:33642383
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8343313/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37a4/8343313/dd5080792612/NRR-16-2012-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37a4/8343313/dd5080792612/NRR-16-2012-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37a4/8343313/dd5080792612/NRR-16-2012-g001.jpg

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Hum Mol Genet. 2020 Nov 25;29(19):3224-3248. doi: 10.1093/hmg/ddaa209.
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GSK3-ARC/Arg3.1 and GSK3-Wnt signaling axes trigger amyloid-β accumulation and neuroinflammation in middle-aged Shugoshin 1 mice.GSK3-ARC/Arg3.1 和 GSK3-Wnt 信号通路在中年 Shugoshin 1 小鼠中引发淀粉样蛋白-β积累和神经炎症。
Aging Cell. 2020 Oct;19(10):e13221. doi: 10.1111/acel.13221. Epub 2020 Aug 28.
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"Amyloid-beta accumulation cycle" as a prevention and/or therapy target for Alzheimer's disease.
淀粉样β 积累周期作为阿尔茨海默病的预防和/或治疗靶点。
Aging Cell. 2020 Mar;19(3):e13109. doi: 10.1111/acel.13109. Epub 2020 Jan 25.
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Chromosome Instability and Mosaic Aneuploidy in Neurodegenerative and Neurodevelopmental Disorders.神经退行性疾病和神经发育障碍中的染色体不稳定性与嵌合非整倍体
Front Genet. 2019 Nov 7;10:1092. doi: 10.3389/fgene.2019.01092. eCollection 2019.
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Alzheimer Disease: An Update on Pathobiology and Treatment Strategies.阿尔茨海默病:病理生物学与治疗策略的最新研究进展。
Cell. 2019 Oct 3;179(2):312-339. doi: 10.1016/j.cell.2019.09.001. Epub 2019 Sep 26.
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