Mehmood Azhar, Khan Suliman, Khan Sajid, Ahmed Saeed, Ali Ashaq, Xue Mengzhou, Ali Liaqat, Hamza Muhammad, Munir Anum, Ur Rehman Saad, Mehmood Khan Arshad, Hussain Shah Abbas, Bai Qian
The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Department of Bioinformatics/Botany, Govt. Postgraduate College Mandian Abbottabad, KPK, Pakistan.
Saudi J Biol Sci. 2021 May;28(5):3137-3151. doi: 10.1016/j.sjbs.2021.02.058. Epub 2021 Feb 23.
Coronavirus disease (COVID-19) is an infection of the respiratory system caused by single standard RNA viruses named as Severe Acute Respiratory Syndrome 2 (SARS-CoV-2). The disease appeared as a serious problem and the leading cause of death in human beings throughout the world. The main source of different phytochemicals are plants, which helps in the development of new drugs against various ailments. Islam is comprehensive religion and a complete code of life for Muslims. The teaching of Islam, according to the Holy Quran and Hadith are universal for the benefit of humanity. Islam believes that every ailment is from God and who made the disease definitely made its medication. There is a complete guideline with regard to taking measures against infectious diseases such as quarantine and seeking medicinal treatment. The research objective is to gather the knowledge of medicinal plants described in the Holy Quran or utilized by the Prophet (SAW) for the treatment of different ailments or advised to use them to boost immunity and strengthen the body. Scientists across the globe have found these plants beneficial for many diseases and have antiviral potential. In present study, the six plant species including and were selected which contain phytochemicals like Calcium Elenolate, Thymoquinone, S-Allylcysteine, Dipropyl Disulfide, Sesquiterpene, Monoterpene, Pelargonidin 3-Galactoside ion and Kaempferol. The phytochemicals monoterpene (from ) shows best interaction with target proteins RdRP, 3CLPro, ACE2. Calcium Elonate (from olive) bonds with 3CLPro, ACE2 and Kemoferol and Pelargomidine (from Senna Makki) bonds with RdRP, ACE2. The ligands show a unique set of intersections i.e. hydrogen bonding, and alkyl interaction. These medicinal plants can be utilized immediately for the treatment of COVID-19 as their safety is already established. This treatment can enhance recovery when combined with other treatments. Furthermore, the screening of bioactive compounds or phytochemicals found in these plants can be utilized to design new therapeutic drug to treat COVID-19 pandemic.
冠状病毒病（COVID-19）是一种由名为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的单链RNA病毒引起的呼吸系统感染。该疾病已成为一个严重问题，是全世界人类死亡的主要原因。不同植物化学物质的主要来源是植物，这有助于开发针对各种疾病的新药。伊斯兰教是全面的宗教，是穆斯林完整的生活准则。根据《古兰经》和圣训，伊斯兰教的教义对全人类有益。伊斯兰教认为，每种疾病都来自真主，创造疾病的真主必定也创造了其治疗方法。对于采取诸如隔离和寻求药物治疗等针对传染病的措施有完整的指导方针。研究目的是收集《古兰经》中描述的或先知（愿主福安之）用于治疗不同疾病或建议用于增强免疫力和强健身体的药用植物的知识。全球科学家已发现这些植物对许多疾病有益且具有抗病毒潜力。在本研究中，选择了六种植物，包括……，它们含有诸如紫铆酸钙、百里醌、S-烯丙基半胱氨酸、二丙基二硫化物、倍半萜、单萜、天竺葵素3-半乳糖苷离子和山奈酚等植物化学物质。植物化学物质单萜（来自……）与目标蛋白RNA依赖性RNA聚合酶（RdRP）、3C样蛋白酶（3CLPro）、血管紧张素转换酶2（ACE2）表现出最佳相互作用。紫铆酸钙（来自橄榄）与3CLPro、ACE2结合，山奈酚和天竺葵素（来自番泻叶）与RdRP和ACE2结合。这些配体表现出独特的一组交叉点，即氢键和烷基相互作用。这些药用植物因其安全性已得到证实，可立即用于治疗COVID-19。这种治疗与其他治疗方法联合使用时可提高康复率。此外，对这些植物中发现的生物活性化合物或植物化学物质的筛选可用于设计治疗COVID-19大流行的新治疗药物。
