小儿颅内夹层动脉瘤的夹闭和血管成形术治疗及二代测序分析：一例报告并文献复习
Treatment of pediatric intracranial dissecting aneurysm with clipping and angioplasty, and next-generation sequencing analysis: A case report and literature review.
作者信息
Sun Ning, Yang Xin-Yu, Zhao Yan, Zhang Qing-Jiang, Ma Xiao, Wei Zhong-Nan, Li Meng-Qi
机构信息
Department of Neurosurgery, Tianjin Children's Hospital/Tianjin University Children's Hospital, Tianjin 300134, China.
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
出版信息
World J Clin Cases. 2021 Feb 16;9(5):1103-1110. doi: 10.12998/wjcc.v9.i5.1103.
BACKGROUND
Large intracranial dissecting aneurysm (IDA) in the anterior cerebral circulation is rare in children. There has been no consensus on the diagnosis and treatment for IDA in children.
CASE SUMMARY
We report a 3-year-old boy with a large ruptured IDA in the right middle cerebral artery (16 mm × 14 mm). The IDA was successfully managed with clipping and angioplasty. Next-generation sequencing of the blood sample followed by bioinformatics analysis suggested that the rs78977446 variant of the gene is a risk for pediatric IDA. Three years after surgery, the boy was develop-mentally normal.
CONCLUSION
Clipping and angioplasty are effective treatments for ruptured IDA in the anterior cerebral circulation. rs78977446 is a risk factor for pediatric IDA.
背景
儿童大脑前循环大型颅内夹层动脉瘤（IDA）较为罕见。对于儿童IDA的诊断和治疗尚无共识。
病例摘要
我们报告一名3岁男孩，其右侧大脑中动脉存在一个大型破裂IDA（16毫米×14毫米）。该IDA通过夹闭和血管成形术成功治疗。对血液样本进行二代测序并经生物信息学分析表明，该基因的rs78977446变异是儿童IDA的一个风险因素。术后三年，该男孩发育正常。
结论
夹闭和血管成形术是治疗大脑前循环破裂IDA的有效方法。rs78977446是儿童IDA的一个风险因素。
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