Watson Ashleigh, Kolinski Julie, Suchi Mariko, Elkadri Abdul
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.
Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin.
ACG Case Rep J. 2021 Feb 23;8(2):e00538. doi: 10.14309/crj.0000000000000538. eCollection 2021 Feb.
Celiac disease is an immune-mediated process against gluten, resulting in inflammation and villous atrophy of the duodenum. Symptoms of malabsorption characterize the classic presentation; however, abdominal pain, constipation, and nutritional deficiencies can also be seen. We present a case of a 4-year-old boy who was found to have celiac disease after presenting with diarrhea, abdominal pain, weight loss, and new-onset pancytopenia. Symptoms resolved, and laboratory values normalized after the initiation of a gluten-free diet, indicating the bone marrow suppression was due to celiac disease, which needs to be considered when hematologic abnormalities are present, even in the absence of gastrointestinal symptoms.
乳糜泻是一种针对麸质的免疫介导过程，导致十二指肠炎症和绒毛萎缩。吸收不良症状是典型表现；然而，也可见腹痛、便秘和营养缺乏。我们报告一例4岁男孩，他在出现腹泻、腹痛、体重减轻和新发全血细胞减少后被诊断为乳糜泻。开始无麸质饮食后症状缓解，实验室检查值恢复正常，表明骨髓抑制是由乳糜泻引起的，即使在没有胃肠道症状的情况下，出现血液学异常时也需要考虑这一病因。
