DeAngelo Christopher, Tarasiewicz Megan Burnett, Strother Athena, Taggart Heather, Gray Caron, Shanahan Meaghan, Glowacki Christopher, Khandalavala Jimmy, Talaska Erin, Kinnan Andrea, Coté John Joseph, Edwards Adrienne Perfilio, Harper-Harrison Gina, Casey Murray Joseph, Hirai Traci-Lynn, Schultz Sarah, Stines Lynnea, Vora Roma, Boudreau Dominique, Burgart Jennifer, Shama Meredith, Watson Trevor, Strasheim Lisa, Thompson Rachel, Lawlor Rachel, Joyce Kayleen, Magnuson Claire M, Driano Jane, Elger Breanna, Lentino Anne, Driscoll Margaret, Tidwell Elise, Sharma Apoorva, Walker Sarah R, Jones Gretchen, Sharma Poonam, Stessman Holly, Wu Yanyuan, Vadgama Jay, Chase Dana, Conrad Lesley, Reddy Srinivasa T, Farias-Eisner Robin
Creighton University School of Medicine, Omaha, NE, United States.
Creighton University School of Medicine; Charles Drew University; David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA, United States.
J Cancer Res Ther Oncol. 2020 Apr;8(2). doi: 10.17303/jcrto.2020.8.206. Epub 2020 Dec 29.
Endometriosis is complex, but identifying the novel biomarkers, inflammatory molecules, and genetic links holds the key to the enhanced detection, prediction and treatment of both endometriosis and endometriosis related malignant neoplasia. Here we review the literature relating to the specific molecular mechanism(s) mediating tumorigenesis arising within endometriosis.
Guidance (e.g. Cochrane) and published studies were identified. The Published studies were identified through PubMed using the systematic review methods filter, and the authors' topic knowledge. These data were reviewed to identify key and relevant articles to create a comprehensive review article to explore the molecular fingerprint associated with in endometriosis-driven tumorigenesis.
An important focus is the link between C3aR1, PGR, ER1, SOX-17 and other relevant gene expression profiles and endometriosis-driven tumorigenesis. Further studies should also focus on the combined use of CA-125 with HE-4, and the role for OVA1/MIA as clinically relevant diagnostic biomarkers in the prediction of endometriosis-driven tumorigenesis.
Elucidating endometriosis' molecular fingerprint is to understand the molecular mechanisms that drive the endometriosis-associated malignant phenotype. A better understanding of the predictive roles of these genes and the value of the biomarker proteins will allow for the derivation of unique molecular treatment algorithms to better serve our patients.
子宫内膜异位症情况复杂，但识别新的生物标志物、炎症分子和基因联系是提高子宫内膜异位症及其相关恶性肿瘤检测、预测和治疗水平的关键。在此，我们综述了与介导子宫内膜异位症相关肿瘤发生的特定分子机制有关的文献。
确定指南（如Cochrane指南）和已发表的研究。通过使用系统评价方法过滤器并借助作者的主题知识，在PubMed上检索已发表的研究。对这些数据进行综述，以确定关键和相关文章，从而撰写一篇全面的综述文章，探讨与子宫内膜异位症驱动的肿瘤发生相关的分子指纹。
一个重要的关注点是C3aR1、PGR、ER1、SOX - 17及其他相关基因表达谱与子宫内膜异位症驱动的肿瘤发生之间的联系。进一步的研究还应聚焦于CA - 125与HE - 4的联合应用，以及OVA1/MIA作为临床相关诊断生物标志物在预测子宫内膜异位症驱动的肿瘤发生中的作用。
阐明子宫内膜异位症的分子指纹有助于了解驱动子宫内膜异位症相关恶性表型的分子机制。更好地理解这些基因的预测作用以及生物标志物蛋白的价值，将有助于推导独特的分子治疗算法，从而更好地为患者服务。
