Sidsworth Danielle A, Sellers Stephanie L, Reutens-Hernandez Jennifer P, Dunn Elizabeth A, Gray Sarah L, Payne Geoffrey W
Northern Medical Program, University of Northern British Columbia, Prince George, BC, V2N 4Z9, Canada.
Centre for Heart Lung Innovation & Department of Radiology, University of British Columba & St. Paul's Hospital, Vancouver, BC, V6Z 1Y6, Canada.
Heliyon. 2021 Feb 12;7(2):e06217. doi: 10.1016/j.heliyon.2021.e06217. eCollection 2021 Feb.
The association of obesity with cardiovascular disease is well established. However, the interplay of obesity and vascular dysfunction in peripheral tissues such as skeletal muscle, which plays a key in role metabolic homeostasis, requires further study. In particular, there is a paucity of data with regard to sex-differences. Therefore, using a murine model (C57BL/6) of high-fat diet-induced obesity and insulin resistance, we investigated changes in vascular function in gluteus maximus muscle of female and male mice. Diet-induced obesity resulted in alterations in microvascular function. Obese male mice displayed impaired vasoconstriction in second order arterioles compared to lean, male mice, whereas arterioles of obese, female mice displayed significant impairments of both vasodilation and vasoconstrictor responses compared to lean, female mice. Overall, this study identifies distinct differences in how obesity impacts the female and male murine response to skeletal muscle vascular function. This work advances our understanding of sex-specific risk of metabolic complications of obesity and indicates the need for expansion of this study as well as detailed investigation of sex-specific differences in obesity pathology in the future.
肥胖与心血管疾病之间的关联已得到充分证实。然而，肥胖与外周组织（如骨骼肌，其在代谢稳态中起关键作用）的血管功能障碍之间的相互作用仍需进一步研究。特别是，关于性别差异的数据很少。因此，我们使用高脂饮食诱导的肥胖和胰岛素抵抗的小鼠模型（C57BL/6），研究了雌性和雄性小鼠臀大肌血管功能的变化。饮食诱导的肥胖导致微血管功能改变。与瘦的雄性小鼠相比，肥胖雄性小鼠的二级小动脉血管收缩功能受损，而与瘦的雌性小鼠相比，肥胖雌性小鼠的小动脉血管舒张和血管收缩反应均有明显受损。总体而言，本研究确定了肥胖对雌性和雄性小鼠骨骼肌血管功能反应影响的明显差异。这项工作推进了我们对肥胖代谢并发症性别特异性风险的理解，并表明未来需要扩展这项研究以及详细调查肥胖病理学中的性别特异性差异。
