Djakpo Dodji Kossi, Wang Zhi Quan, Shrestha Merina
Zhongnan Hospital of Wuhan University, Wuhan, China.
Arch Med Sci Atheroscler Dis. 2020 Dec 26;5:e279-e283. doi: 10.5114/amsad.2020.103028. eCollection 2020.
Fernando De Ritis described the significance of the transaminase (AST/ALT) ratio in 1957, and since then it has been commonly used to screen liver diseases. The liver is sensitive to hemodynamic changes because it receives approximately one-quarter of total cardiac output. We aimed to investigate the AST/ALT ratio changes in patients with acute myocardial infarction without any history of liver diseases in the Chinese Han population.
We analyzed a total of 120 patients with acute myocardial infarction admitted to the cardiology department of Zhongnan Hospital of Wuhan University between January 2019 and June 2019. AST/ALT ratio of the first blood test was calculated for all patients.
The mean De Ritis ratio (AST/ALT) was higher in patients with ST-segment elevation myocardial infarction (STEMI) (3.2261 ±2.41379) than in non-ST-segment elevation myocardial infarction (NSTEMI) (2.2089 ±1.63177) patients. The difference was statistically significant ( = 0.002).
AST/ALT ≥ 2.0 has a strong association with total coronary occlusion. We might rely on this test to predict coronary occlusion without age difference.
费尔南多·德·里蒂斯于1957年描述了转氨酶（AST/ALT）比值的意义，自那时起它就被广泛用于肝病筛查。肝脏对血流动力学变化敏感，因为它接受大约四分之一的心输出量。我们旨在研究中国汉族人群中无肝脏疾病史的急性心肌梗死患者的AST/ALT比值变化。
我们分析了2019年1月至2019年6月期间武汉大学中南医院心内科收治的120例急性心肌梗死患者。计算所有患者首次血液检测的AST/ALT比值。
ST段抬高型心肌梗死（STEMI）患者的平均德·里蒂斯比值（AST/ALT）（3.2261±2.41379）高于非ST段抬高型心肌梗死（NSTEMI）患者（2.2089±1.63177）。差异具有统计学意义（=0.002）。
AST/ALT≥2.0与冠状动脉完全闭塞密切相关。我们可以依靠这项检测来预测冠状动脉闭塞，且不存在年龄差异。
