整合免疫代谢信号以维持健康衰老。
Integration of immune-metabolic signals to preserve healthy aging.
作者信息
Goldberg Emily L
机构信息
Department of Physiology, University of California, 1550 4th St, San Francisco, CA, 94158, USA.
出版信息
Transl Med Aging. 2020;4:93-95. doi: 10.1016/j.tma.2020.07.005. Epub 2020 Jul 24.
Abstract
Inflammation is a broad term that refers to a collection of carefully balanced programs in the body. These pathways are essential for detecting invading microorganisms, controlling the spread of infection, and instructing appropriate immune responses to eliminate pathogens. During aging there is deterioration of important regulatory mechanisms, giving rise to persistent low-grade inflammation that drives chronic conditions such as metabolic dysregulation, immune senescence, and cognitive decline. Understanding this aspect of the pathobiology of aging is key to uncovering the source(s) and cause(s) of age-related inflammation that underlies disease.
摘要
炎症是一个宽泛的术语，指的是身体中一系列精心平衡的程序。这些途径对于检测入侵的微生物、控制感染的传播以及指导适当的免疫反应以消除病原体至关重要。在衰老过程中，重要的调节机制会恶化，导致持续性的低度炎症，从而引发诸如代谢失调、免疫衰老和认知衰退等慢性疾病。了解衰老病理生物学的这一方面是揭示与年龄相关的炎症的根源以及导致疾病的原因的关键。
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