HHMI and Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Development. 2023 Jan 15;150(2). doi: 10.1242/dev.201037. Epub 2023 Jan 30.
A hallmark of all germ cells is the presence of germ granules: assemblies of proteins and RNA that lack a delineating membrane and are proposed to form via condensation. Germ granules across organisms share several conserved components, including factors required for germ cell fate determination and maintenance, and are thought to be linked to germ cell development. The molecular functions of germ granules, however, remain incompletely understood. In this Development at a Glance article, we survey germ granules across organisms and developmental stages, and highlight emerging themes regarding granule regulation, dynamics and proposed functions.
蛋白质和 RNA 的集合，缺乏界定的膜，并通过浓缩形成。生物体中的生殖颗粒共享几个保守的成分，包括生殖细胞命运决定和维持所需的因子，并且被认为与生殖细胞发育有关。然而，生殖颗粒的分子功能仍不完全清楚。在这篇发展概览文章中，我们调查了跨生物体和发育阶段的生殖颗粒，并强调了关于颗粒调节、动态和拟议功能的新兴主题。
