Adamson G D
Department of Obstetrics and Gynecology, Stanford University School of Medicine, Palo Alto, CA 94301.
Am J Obstet Gynecol. 1988 Apr;158(4):1002-5. doi: 10.1016/0002-9378(88)90114-7.
Butoconazole nitrate, a newer imidazole, is effective for the treatment of vulvovaginal candidiasis when administered as a vaginal cream. The microbiologic and clinical cure rates achieved with a 3-day course of butoconazole 2% cream have been comparable with those obtained with a 6-day course of miconazole nitrate 2% cream or a 3-day course of clotrimazole vaginal tablets (200 mg/day). Patients taking oral contraceptives have responded as favorably as those using other forms of birth control or none whatsoever. In addition, both microbiologic and clinical cures resulting from a 3-day regimen of butoconazole 2% cream have been sustained for at least 4 weeks. The high degree of efficacy and safety demonstrated by this short treatment regimen offers an advantage in the management of patients with vulvovaginal candidiasis, many of whom are likely to abandon any therapy as soon as their clinical symptoms have subsided. A clinical assessment of butoconazole vaginal suppositories (100 mg/day) and clotrimazole vaginal tablets (200 mg/day) found that the two therapies were comparably safe and effective when administered for 3 days. The suppository form of butoconazole may offer a valuable therapeutic alternative for patients who wish to use it instead of or in conjunction with vaginal cream.
硝酸布康唑是一种较新的咪唑类药物，以阴道乳膏形式给药时，对治疗外阴阴道念珠菌病有效。使用2%硝酸布康唑乳膏进行为期3天的疗程所达到的微生物学和临床治愈率，与使用2%硝酸咪康唑乳膏进行为期6天的疗程或克霉唑阴道片（200毫克/天）进行为期3天的疗程所获得的治愈率相当。服用口服避孕药的患者与使用其他避孕方式或未采取任何避孕措施的患者反应一样良好。此外，2%硝酸布康唑乳膏进行为期3天的疗程所带来的微生物学和临床治愈效果至少持续了4周。这种短疗程所显示出的高度疗效和安全性，在管理外阴阴道念珠菌病患者方面具有优势，因为许多患者一旦临床症状消退，很可能就会放弃任何治疗。对硝酸布康唑阴道栓剂（100毫克/天）和克霉唑阴道片（200毫克/天）的临床评估发现，两种疗法在给药3天时安全性和有效性相当。硝酸布康唑的栓剂形式可能为希望使用它而非阴道乳膏或与阴道乳膏联合使用的患者提供一种有价值的治疗选择。
