Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Department of Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
J Magn Reson Imaging. 2021 Jul;54(1):155-165. doi: 10.1002/jmri.27574. Epub 2021 Feb 28.
Adipose tissue has recently gained interest as an independent imaging biomarker for osteoarthritis.
To explore 1) cross-sectional associations between local subcutaneous fat (SCF) thickness at the knee and the extent of degenerative changes in overweight and obese individuals and 2) associations between local fat distribution and progression of osteoarthritis over 4 years.
Retrospective cohort study.
338 obese and overweight participants from the Osteoarthritis Initiative cohort without radiographic evidence of osteoarthritis.
3T: 3D-FLASH-WE; 3D-DESS-WE; T1w-SE; MSME.
Baseline SCF thickness was measured in standardized locations medial, lateral and anterior to the knee and the average joint-adjacent SCF (ajSCF) was calculated. Right thigh SCF cross-sectional area was assessed. Quantitative cartilage T relaxation times and semi-quantitative whole organ MRI scores (WORMS) were obtained at baseline and 4-year follow-up. WORMS was calculated as sum of cartilage, bone marrow edema, subchondral cyst, and meniscal scores.
Associations of SCF measures with baseline, and 4-year change in T and WORMS were analyzed using regression models. SCF measurements were standardized using the equation . Analyses were adjusted for age, sex, physical activity, and BMI.
Cross-sectionally, significant associations between lateral SCF, lateral compartment WORMS and T were found ( , [95% CI]: 0.53, [0.12-0.95], P < 0.05; ΔT : 0.50, [0.02-0.98], P < 0.05). Moreover, greater lateral SCF was associated with faster progression of lateral WORMS gradings (OR = 1.50, [1.05-2.15], P < 0.05). No significant positive associations were found for thigh SCF and WORMS (P = 0.44) or T measurements (medial: P = 0.15, lateral: 0.39, patellar: P = 0.75).
Joint-adjacent SCF thickness was associated with imaging parameters of knee osteoarthritis, both cross-sectionally and longitudinally, while thigh SCF was not, suggesting a spatial association of SCF and knee osteoarthritis. Based on these findings, joint-adjacent SCF may play a role in the development and progression of knee osteoarthritis.
4 TECHNICAL EFFICACY: Stage 5.
脂肪组织最近作为骨关节炎的独立影像学生物标志物引起了关注。
探讨 1）超重和肥胖个体膝关节局部皮下脂肪 (SCF) 厚度与退行性改变程度的横断面相关性，以及 2）局部脂肪分布与 4 年内骨关节炎进展的相关性。
回顾性队列研究。
来自 Osteoarthritis Initiative 队列的 338 名超重和肥胖参与者，无影像学证据表明患有骨关节炎。
3T：3D-FLASH-WE；3D-DESS-WE；T1w-SE；MSME。
在膝关节内侧、外侧和前侧的标准化位置测量基线时的 SCF 厚度，并计算平均关节旁 SCF (ajSCF)。评估右大腿 SCF 横截面积。在基线和 4 年随访时获得定量软骨 T 弛豫时间和半定量全器官 MRI 评分 (WORMS)。WORMS 计算为软骨、骨髓水肿、软骨下囊肿和半月板评分的总和。
使用回归模型分析 SCF 测量值与基线和 4 年 T 和 WORMS 变化的相关性。使用方程 对 SCF 测量值进行标准化。分析调整了年龄、性别、体力活动和 BMI。
横断面研究发现，外侧 SCF 与外侧关节腔 WORMS 和 T 之间存在显著相关性（ ，[95%CI]：0.53，[0.12-0.95]，P<0.05；ΔT：0.50，[0.02-0.98]，P<0.05）。此外，外侧 SCF 越大，外侧 WORMS 分级的进展速度越快（OR=1.50，[1.05-2.15]，P<0.05）。大腿 SCF 与 WORMS（P=0.44）或 T 测量值（内侧：P=0.15，外侧：P=0.39，髌股关节：P=0.75）之间无显著正相关关系。
关节旁 SCF 厚度与膝关节骨关节炎的影像学参数相关，无论是横断面还是纵向，而大腿 SCF 则不相关，这表明 SCF 与膝关节骨关节炎之间存在空间关联。基于这些发现，关节旁 SCF 可能在膝关节骨关节炎的发生和进展中发挥作用。
4 级
5 级
