Park J M, Ewing K, Miller F, Friedman C I, Kim M H
Department of Obstetrics and Gynecology, Ohio State University, Columbus.
Am J Obstet Gynecol. 1988 Apr;158(4):974-9. doi: 10.1016/0002-9378(88)90105-6.
Relaxin, a polypeptide hormone found in human seminal plasma, exerted favorable effects on the function of spermatozoa. This study was designed to investigate the effect of this hormone on the fertilization capacity of human spermatozoa from 10 oligospermic men (group A), 11 asthenospermic men (group B), 10 normospermic infertile men (group C), and 10 men with verified fertility (group D). We compared the effects of purified porcine relaxin at different concentrations (0, 50, and 150 ng/ml). Parameters include motility, hypoosmolar swelling test, and zona-free hamster egg penetration test. In group A and group B, relaxin increased the results of the hamster egg penetration test and motility. In group C, results of the hamster egg penetration test and motility improved only at the concentration of 50 ng/ml. In group D, relaxin increased the results of the hamster egg penetration test only at a concentration of 150 ng/ml. Results of the hypoosmolar swelling test were not consistently altered in any study group. Relaxin appears to enhance the fertilization capacity and motility of human spermatozoa in oligospermic and asthenospermic subjects.
松弛素是一种存在于人类精液中的多肽激素，对精子功能具有有益作用。本研究旨在调查该激素对10名少精子症男性（A组）、11名弱精子症男性（B组）、10名正常精子症不育男性（C组）和10名已证实有生育能力男性（D组）的人类精子受精能力的影响。我们比较了不同浓度（0、50和150 ng/ml）的纯化猪松弛素的作用。参数包括活力、低渗肿胀试验和去透明带仓鼠卵穿透试验。在A组和B组中，松弛素提高了仓鼠卵穿透试验结果和活力。在C组中，仅在50 ng/ml浓度时仓鼠卵穿透试验结果和活力有所改善。在D组中，松弛素仅在150 ng/ml浓度时提高了仓鼠卵穿透试验结果。低渗肿胀试验结果在任何研究组中均未持续改变。松弛素似乎可增强少精子症和弱精子症患者的人类精子受精能力和活力。
