Division of Microbiology and Molecular Genetics, Alumni Hall for Basic Sciences, Loma Linda University, Loma Linda, CA, 92350, USA.
Division of Microbiology and Molecular Genetics, Alumni Hall for Basic Sciences, Loma Linda University, Loma Linda, CA, 92350, USA.
Curr Opin Microbiol. 2021 Jun;61:8-15. doi: 10.1016/j.mib.2021.01.004. Epub 2021 Feb 26.
PAS domains are widespread, versatile domains found in proteins from all kingdoms of life. The PAS fold is composed of an antiparallel β-sheet with several flanking α-helices, and contains a conserved cleft for cofactor or ligand binding. The last few years have seen a prodigious increase in identified PAS domains and resolved PAS structures, including structures with effector and other domains. New bacterial PAS ligands have been discovered, and structure-function studies have improved our understanding of PAS signaling mechanisms. The list of bacterial PAS functions has now expanded to include roles in signal sensing, modulation, transduction, dimerization, protein interaction, and cellular localization.
PAS 结构域广泛存在于所有生命领域的蛋白质中，是一种多功能结构域。PAS 折叠由一个具有几个侧翼α-螺旋的反平行β-片层组成，并包含一个保守的裂隙，用于结合辅助因子或配体。在过去的几年中，已经发现了大量的 PAS 结构域和解析的 PAS 结构，包括具有效应子和其他结构域的结构。已经发现了新的细菌 PAS 配体，并且结构-功能研究提高了我们对 PAS 信号转导机制的理解。细菌 PAS 功能的清单现在已经扩展到包括在信号感应、调节、转导、二聚化、蛋白质相互作用和细胞定位中的作用。
