Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada.
Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada.
Curr Opin Immunol. 2021 Apr;69:39-46. doi: 10.1016/j.coi.2021.01.002. Epub 2021 Feb 26.
The microbiome is a potent modulator of host immune responses and over the past years has been shown to impact tumor immunology. Both pro-tumorigenic and anti-tumorigenic functions have been associated with the microbiome and functional studies have pinpointed specific anti-tumor immunity-promoting microbes, such as Akkermansia muciniphila and Bifidobacterium longum. The identification of key host genes and microbe-derived signals involved in anti-tumor immunity is still in its infancy. Here we focus on recent advances in this area, revealing host molecules found to be central in host-microbiome dependent modulation of tumor immunity, and highlight key questions to be tackled in the field.
微生物组是宿主免疫反应的有力调节剂，近年来已被证明会影响肿瘤免疫学。微生物组与促肿瘤和抗肿瘤功能都有关联，功能研究已经确定了一些具有特定抗肿瘤免疫促进作用的微生物，如阿克曼氏菌和长双歧杆菌。参与抗肿瘤免疫的关键宿主基因和微生物衍生信号的鉴定仍处于起步阶段。在这里，我们关注该领域的最新进展，揭示了在宿主-微生物依赖的肿瘤免疫调节中发现的核心宿主分子，并强调了该领域需要解决的关键问题。
