Int J Sports Physiol Perform. 2021 Sep 1;16(9):1253-1260. doi: 10.1123/ijspp.2020-0352. Epub 2021 Mar 1.
Plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T levels show a transient increase after marathon running. The aim of this study was to investigate whether running duration influences the patterns of changes in cardiac biomarkers.
Twenty participants with fast and slow finishing times were included in the study. Blood samples were taken before the marathon race, immediately after, and 24 hours after the race. Samples were analyzed for NT-proBNP and cardiac troponin T concentration. Furthermore, a complete blood cell count was performed.
After the marathon race, the fast and slow runners showed similar changes of NT-proBNP and cardiac troponin T (ie, a transient increase). Curve estimation regression analysis showed a curvilinear relationship (quadratic model) between running times and NT-proBNP increments immediately after the race, with less of an increase in the very fast and the very slow runners (r2 = .359, P = .023). NT-proBNP increments immediately after the race were correlated to the decline 24 hours after the marathon (r = -.612, P = .004).
This study indicates that NT-proBNP release immediately after marathon running varies in a curvilinear fashion with running time. It is speculated that low NT-proBNP release is associated with training adaptation in most elite runners and the relatively low cardiac stress in the slowest (but experienced) runners. The combination of less adaptation and relatively large cardiac wall and metabolic stress may explain the highest NT-proBNP values in runners with average running times. In addition, NT-proBNP decrements 24 hours after the race depend primarily on the values reached after the marathon and not on running time.
血浆 N 末端脑利钠肽前体（NT-proBNP）和心肌肌钙蛋白 T 水平在马拉松跑步后会短暂升高。本研究旨在探讨跑步持续时间是否会影响心脏生物标志物变化的模式。
本研究纳入了 20 名完成时间较快和较慢的参与者。在马拉松比赛前、比赛后即刻和比赛后 24 小时采集血液样本，分析 NT-proBNP 和心肌肌钙蛋白 T 浓度。此外，还进行了全血细胞计数。
马拉松比赛后，快速和慢速跑步者的 NT-proBNP 和心肌肌钙蛋白 T 均呈现相似的变化（即短暂升高）。曲线估计回归分析显示，比赛后即刻 NT-proBNP 增加与跑步时间之间呈曲线关系（二次模型），非常快速和非常慢速跑步者的增加幅度较小（r2 =.359，P =.023）。比赛后即刻 NT-proBNP 的增加与马拉松 24 小时后的下降呈负相关（r = -.612，P =.004）。
本研究表明，马拉松比赛后即刻 NT-proBNP 的释放与跑步时间呈曲线变化。推测在大多数精英跑步者中，NT-proBNP 的低释放与训练适应有关，而在最慢（但经验丰富）的跑步者中，心脏的相对压力较小。适应能力较低和相对较大的心脏壁和代谢压力的组合可能解释了平均跑步时间的跑步者的 NT-proBNP 值最高。此外，马拉松赛后 24 小时 NT-proBNP 的下降主要取决于马拉松赛后的数值，而不是跑步时间。
