D'Alleva M, Sanz J M, Giovanelli N, Graniero F, Mari L, Spaggiari R, Sergi D, Ghisellini S, Passaro A, Lazzer S
Department of Medicine, University of Udine, P. le Kolbe 4 - 33100, Udine, Italy.
School of Sport Sciences, University of Udine, Udine, Italy.
Eur J Appl Physiol. 2025 May;125(5):1485-1500. doi: 10.1007/s00421-024-05697-8. Epub 2025 Jan 9.
The aim of this study was to investigate the influence of prolonged aerobic exercise on cardiac, muscular and renal inflammatory markers in a group of trained obese men.
Seventeen men (aged 40 ± 6 years; body mass index [BMI] 31.3 ± 2.8 kg m, maximal oxygen uptake [V'Omax] 41.5 ± 5.6 ml kg min) ran a half, 30 km, or full marathon. Troponin I (cTnI), the n-terminal creatine kinase-myocardial band (CK-MB), pro b-type natriuretic peptide (NT-proBNP), lactate dehydrogenase (LDH), myoglobin, creatinine (CREA) and the estimated glomerular filtration rate (eGFR) were measured before (T0), immediately after (T1) and 3 days after the race (T2).
The concentrations of cTnI, myoglobin, LDH, CK-MB and CREA significantly increased (P < 0.05), whereas eGRF decreased at T1 (P < 0.05). All the above parameters returned to baseline at T2, except for eGFR, which remained lower than that at T0 (P < 0.05). A positive association was observed between ΔCK-MB (%) and the time spent in Zone 3 during the race (R = 0.686, P = 0.014). The Δmyoglobin (%) was positively correlated with race time, race mean speed and time in Zone 3 (R = 0.574-0.862, P < 0.05). The ∆CREA values were moderately correlated with the race mean HR (%) and time spent in Zone 3 (%) (R = 0.514-0.610; P = 0.05). The ∆eGRF values were moderately inversely correlated with the time spent in Zone 3 (%) (R = - 0.627; P < 0.05).
Changes in cardiac, muscular and renal inflammatory markers in trained men with obesity are consistent with those described in the literature in normal-weight individuals. Finally, running parameters, such as running time, average running intensity and time in Zone 3 appear to be responsible for the changes in cardiac, muscular and renal function markers after long-distance running.
本研究旨在调查长期有氧运动对一组肥胖男性训练者心脏、肌肉和肾脏炎症标志物的影响。
17名男性（年龄40±6岁；体重指数[BMI]31.3±2.8kg/m，最大摄氧量[V'Omax]41.5±5.6ml/kg/min）参加了半程、30公里或全程马拉松比赛。在比赛前（T0）、比赛结束后即刻（T1）和比赛后3天（T2）测量肌钙蛋白I（cTnI）、N端肌酸激酶心肌带（CK-MB）、B型利钠肽原（NT-proBNP）、乳酸脱氢酶（LDH）、肌红蛋白、肌酐（CREA）和估算肾小球滤过率（eGFR）。
cTnI、肌红蛋白、LDH、CK-MB和CREA的浓度显著升高（P<0.05），而eGFR在T1时降低（P<0.05）。除eGFR仍低于T0时（P<0.05）外，上述所有参数在T2时均恢复至基线水平。观察到ΔCK-MB（%）与比赛期间在第3区所花费的时间之间存在正相关（R=0.686，P=0.014）。Δ肌红蛋白（%）与比赛时间、比赛平均速度和在第3区的时间呈正相关（R=0.574-0.862，P<0.05）。∆CREA值与比赛平均心率（%）和在第3区所花费的时间（%）中度相关（R=0.514-0.610；P=0.05）。∆eGFR值与在第3区所花费的时间（%）中度负相关（R=-0.627；P<0.05）。
肥胖男性训练者心脏、肌肉和肾脏炎症标志物的变化与文献中描述的正常体重个体的变化一致。最后，跑步参数，如跑步时间、平均跑步强度和在第3区的时间，似乎是长跑后心脏、肌肉和肾脏功能标志物变化的原因。
