Dellinger A, Marchand A, Zoheir F, Kirkorian G, Touboul P
Service de Soins Intensifs Cardiologiques, Hôpital Cardiovasculaire, Lyon.
Ann Fr Anesth Reanim. 1988;7(2):128-31. doi: 10.1016/s0750-7658(88)80140-0.
A controlled study was carried out, comparing etomidate and thiopentone used for anaesthesia for cardioversion. Eighty patients presenting with supraventricular tachyarrhythmias were randomly allocated to two groups with stratification for duration of supraventricular tachyarrhythmias and cardiothoracic ratio. After premedication with 10 mg of diazepam, anaesthesia was induced and maintained if necessary with etomidate (0.3 and 0.15 mg.kg-1 respectively) or thiopentone (3 and 1.5 mg.kg-1 respectively). The following observations were made by an independent observer: energy of the electric discharge, systolic and diastolic arterial pressures, heart rate, apnoea with duration, quality of anaesthesia, side-effects if present, and induction, anaesthesia and recovery times. A drawing test and an ambulation test were carried out after recovery. Data were analysed using one-way analysis of variance (continuous variables) and chi-squared test with Yates correction for small numbers (categorical variables) with p less than 0.05 considered significant. The thiopentone (THIO) and etomidate (ETO) groups were similar, except for premedication and number of NYHA class III and IV patients, being more common in ETO (p = 0.04; p = 0.05). Anaesthesia time was 4.6 +/- 2.3 min in THIO and 9.9 +/- 3.5 min in ETO (p less than 10(-9)) with more reinjections in THIO (p = 0.003). Awakening time was shorter in THIO (p less than 10(-6)) and graphic test was carried out better at 15 min in THIO. No difference was found later for graphic test and ambulation. Apnoea was more frequent in THIO (p = 0.002).(ABSTRACT TRUNCATED AT 250 WORDS)
进行了一项对照研究，比较依托咪酯和硫喷妥钠用于心脏复律麻醉的效果。80例室上性快速心律失常患者按室上性快速心律失常持续时间和心胸比率分层，随机分为两组。在给予10mg地西泮进行术前用药后，必要时分别用依托咪酯（分别为0.3和0.15mg·kg-1）或硫喷妥钠（分别为3和1.5mg·kg-1）诱导和维持麻醉。由一名独立观察者进行以下观察：放电能量、动脉收缩压和舒张压、心率、呼吸暂停持续时间、麻醉质量、是否存在副作用以及诱导、麻醉和恢复时间。恢复后进行绘画测试和行走测试。使用单因素方差分析（连续变量）和带有Yates校正的卡方检验（分类变量）分析数据，p值小于0.05被认为具有统计学意义。硫喷妥钠（THIO）组和依托咪酯（ETO）组除术前用药以及纽约心脏协会III级和IV级患者数量外相似，ETO组中这些情况更常见（p = 0.04；p = 0.05）。THIO组麻醉时间为4.6±2.3分钟，ETO组为9.9±3.5分钟（p小于10-9），THIO组再次注射更多（p = 0.003）。THIO组苏醒时间更短（p小于10-6），THIO组在15分钟时绘画测试表现更好。之后绘画测试和行走测试未发现差异。THIO组呼吸暂停更频繁（p = 0.002）。（摘要截短为250字）
