Department of Ophthalmology, Pasteur 2 Teaching Hospital, Nice, France.
Pole Vision, Ecully, France.
Eur J Ophthalmol. 2022 Jan;32(1):402-409. doi: 10.1177/1120672121999348. Epub 2021 Mar 1.
The principal aim of this pilot study was to investigate the concordance between the different stages of Age-Related Macular Degeneration (AMD), as determined by the simplified classification of the Age Related Eye Disease Study Group (AREDS), and new evaluation criteria using a microperimetry system.
A complete eye examination and a microperimetry MAIATM (Macular Integrity Assessment, CenterVue, Padova, Italy) examination was performed on 59 eyes with early, intermediate or advanced AMD. We analysed 19 evaluation criteria for every clinical group category.
There were 20 female and 12 male participants included with a median age of 74 years (min: 54, max: 87). Thirteen eyes (22%) were classified as category 1, 11 eyes (18.6%) as category 2, 17 eyes (28.8%) as category 3 and 18 eyes (30.6%) as category 4 AMD.All evaluated microperimetry criteria related to retinal sensitivity were found to have a statistically significant difference among the stages ( < 0.05). Fixation stability was unstable in 55.6% of the eyes classified as stage 4 ( = 0.001). The analysis of the distance between the two PRLs - PRL_initial and PRL_final was larger for the stage 4 ( = 0.0258). The mean sensitivity in stages 2 and 3 correlated with the presence or not of reticular pseudodrusen ( = 0.0137).
The mean sensitivity and the categorized sensitivity (set to 25, 15 and 5 dB), the five higher and lower stimuli sensitivity appeared to be the most sensitive criteria to differentiate the four AMD categories. Microperimetry provides a new reproducible method of anatomical-functional macular analysis.
本初步研究的主要目的是通过使用微视野计系统，调查由年龄相关性眼病研究组（AREDS）简化分类确定的不同年龄相关性黄斑变性（AMD）阶段之间的一致性，并评估新的评估标准。
对 59 只患有早期、中期或晚期 AMD 的眼睛进行全面的眼部检查和微视野计 MAIATM（黄斑完整性评估，CenterVue，帕多瓦，意大利）检查。我们对每个临床分组类别分析了 19 项评估标准。
共纳入 20 名女性和 12 名男性参与者，中位年龄为 74 岁（最小：54 岁，最大：87 岁）。13 只眼睛（22%）被归类为 1 类，11 只眼睛（18.6%）为 2 类，17 只眼睛（28.8%）为 3 类，18 只眼睛（30.6%）为 4 类 AMD。所有评估的与视网膜敏感性相关的微视野计标准在各阶段之间均存在统计学差异（ < 0.05）。4 期（ = 0.001）中有 55.6%的眼睛固视稳定性不稳定。PRL_initial 和 PRL_final 之间的两个 PR 的距离分析，4 期更大（ = 0.0258）。2 期和 3 期的平均敏感性与是否存在网状假性色素沉着有关（ = 0.0137）。
平均敏感性和分类敏感性（设定为 25、15 和 5 dB）、五个更高和更低的刺激敏感性似乎是区分 AMD 四个阶段最敏感的标准。微视野计提供了一种新的、可重复的解剖功能黄斑分析方法。
