National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi, USA.
Division of Pharmacognosy, Department of BioMolecular Sciences School of Pharmacy, University of Mississippi, University, Mississippi, USA.
Nat Prod Res. 2022 Aug;36(15):3850-3857. doi: 10.1080/14786419.2021.1892668. Epub 2021 Mar 1.
In an attempt to find species specific markers, a phenoxychromone () and eight isoflavonoids including six isoflavans () and two isoflavanones ( and ) were isolated from the root of . Among the isolated phenolic compounds, glycyurelone (), glycyurelvanins A and B ( and ) were found to be undescribed while others, (-)-vestitol (), conferol A (), glyasperin C (), glyasperin D (), (-)-licoisoflavanone (), and (-)-3'-(γ,γ-dimethylallyl)kievitone () were previously reported. All compounds except and were prenylated and majority of these possess isoflavan scaffold with highly conserved stereo specificity at C-3 center. Structure elucidation was mainly based on extensive NMR, ECD and mass spectral data analysis.
为了寻找具有物种特异性的标记物，从 的根部分离得到苯并色酮（）和八种异黄酮，包括六种异黄烷（）和两种异黄酮酮（和）。在所分离的酚类化合物中，发现glycyurelone（）、glycyurelvanins A 和 B（和）是未描述的，而其他化合物，（-）-vestitol（）、conferol A（）、glyasperin C（）、glyasperin D（）、（-）-licoisoflavanone（）和（-）-3'-(γ,γ-二甲基烯丙基）kievitone（）以前曾有报道。除了和之外，所有化合物都被 prenylated，其中大多数具有异黄烷骨架，并在 C-3 中心具有高度保守的立体特异性。结构阐明主要基于广泛的 NMR、ECD 和质谱数据分析。
