Bulacio Lucía, Ramadán Silvana, Dalmaso Hernán, Luque Alicia, Sortino Maximiliano
Centro de Referencia de Micología (CEREMIC), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.
Centro de Referencia de Micología (CEREMIC), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.
Rev Argent Microbiol. 2021 Oct-Dec;53(4):287-291. doi: 10.1016/j.ram.2020.12.006. Epub 2021 Feb 27.
Oral infections due to yeasts of the genus Candida are very common in patients with predisposing factors, such as physiological conditions or certain underlying diseases. Moreover, oral candidiasis can also evolve into disseminated forms. In this work, strains of the genus Candida were studied to establish the optimal radiation conditions for photosensitizing compounds, in a photodynamic antifungal therapy protocol. A total of 39 isolates were evaluated. The strains were exposed to twelve dyestuffs, eight radiation sources and three different exposure times. Orthotoluidine blue exhibited good photodynamic activity, in combination with exposure to a 20W reflector lamp LED (light-emitting diode) light for 60minutes. When considering the difficulties of using conventional antifungal drugs, the emergence of resistant strains, recurrences, and adverse reactions of certain commonly used drugs, the photodynamic antifungal therapy is a promising strategy for the treatment of localized infections.
念珠菌属酵母菌引起的口腔感染在具有易感因素的患者中非常常见，这些因素包括生理状况或某些基础疾病。此外，口腔念珠菌病也可能发展为播散性形式。在这项工作中，研究了念珠菌属菌株，以确定光动力抗真菌治疗方案中光敏化合物的最佳辐射条件。总共评估了39株分离株。这些菌株分别暴露于12种染料、8种辐射源和3种不同的暴露时间。邻甲苯胺蓝与20W反射灯LED（发光二极管）光照60分钟相结合时，表现出良好的光动力活性。考虑到使用传统抗真菌药物的困难、耐药菌株的出现、复发以及某些常用药物的不良反应，光动力抗真菌治疗是治疗局部感染的一种有前景的策略。
