Dpt of Dermatology and Inserm Unit 1098 RIGHT, University of Franche Comté and University Hospital, Besançon, France.
Eur J Dermatol. 2021 Feb 1;31(1):81-85. doi: 10.1684/ejd.2021.3969.
Dissecting cellulitis of the scalp (DCS), also known as Hoffmann disease or perifolliculitis capitis abscedens et suffodiens, is a rare disease characterized by chronic inflammation of the scalp. Treatment is difficult and often disappointing.
To report our experience of TNF inhibitors in a series of patients with DCS.
MATERIALS & METHODS: We conducted a monocentric retrospective study of nine patients with DCS treated with TNF blocker after failure of other conventional treatments.
After a mean duration of treatment by TNF inhibitors of 17 ± 16 months, four patients (44% versus 0%) had a Physician's Global Assessment score of 0 or 1. We observed a 67% reduction in the number of inflammatory nodules, an 88% reduction in purulent drainage and a 45% improvement in Dermatology Life Quality Index. The mean treatment satisfaction index was 6.6 ± 1.6 out of 10.
Our study suggests that TNF inhibitors are effective against disease activity and may improve quality of life in the management of DCS refractory to conventional treatments.
头皮解剖性蜂窝织炎（DCS），也称为 Hoffmann 病或毛囊周围炎伴脓肿穿掘，是一种以头皮慢性炎症为特征的罕见疾病。治疗困难，往往令人失望。
报告我们在一系列 DCS 患者中使用 TNF 抑制剂的经验。
我们对 9 例经其他常规治疗失败后接受 TNF 阻滞剂治疗的 DCS 患者进行了单中心回顾性研究。
在 TNF 抑制剂治疗的平均持续时间为 17±16 个月后，4 名患者（44%比 0%）的医师整体评估评分达到 0 或 1。我们观察到炎症性结节的数量减少了 67%，脓性分泌物减少了 88%，皮肤病生活质量指数改善了 45%。平均治疗满意度指数为 10 分中的 6.6±1.6 分。
我们的研究表明，TNF 抑制剂对疾病活动有效，并可能改善难治性 DCS 常规治疗的生活质量。
