Alzahrani Muslih, Coste Victor, Konstantinou Maria Polina, Reguiai Ziad, Villani Axel, Hotz Claire, Viguier Manuelle, Pruvost-Balland Christelle, Dupuy Alain, Wolkenstein Pierre, Brun Aurore, Aubin François, Sérézal Irène Gallais
Sce de Dermatologie, CHU et Inserm1098, Besançon, France.
Sce de Dermatologie, CHU de Toulouse, France.
Clin Exp Dermatol. 2023 Apr 27;48(5):528-530. doi: 10.1093/ced/llad036.
Although retinoids are considered as the most effective treatment, management of dissecting cellulitis of the scalp (DCS) is often challenging. A multicentre retrospective study was conducted to evaluate the efficacy of anti-tumour necrosis factor (TNF) agents in treating DCS after failure of other conventional treatments. Twenty-six patients were included. After a mean treatment duration of 19 months (SD 21), the median Physician's Global Assessment score decreased from 3 to 1. The median number of inflammatory nodules and abscesses decreased from 7 to 0.5 and from 1 to 0, respectively. The median Dermatology Life Quality Index and numerical rating scale score for pain severity decreased from 10 to 8 and 6 to 1, respectively. The median treatment satisfaction was 7 out of 10 on the Patient Satisfaction Index. This study confirms the efficacy of anti-TNF agents in treating patients with DCS that is resistant to conventional therapies.
尽管维甲酸被认为是最有效的治疗方法，但头皮穿掘性蜂窝织炎（DCS）的治疗往往具有挑战性。开展了一项多中心回顾性研究，以评估抗肿瘤坏死因子（TNF）药物在其他传统治疗失败后治疗DCS的疗效。纳入了26例患者。平均治疗时长为19个月（标准差21）后，医师整体评估评分中位数从3降至1。炎性结节和脓肿的中位数分别从7个降至0.5个以及从1个降至0个。皮肤病生活质量指数中位数和疼痛严重程度数字评定量表评分分别从10降至8以及从6降至1。患者满意度指数的治疗满意度中位数为十分制的7分。本研究证实了抗TNF药物在治疗对传统疗法耐药的DCS患者中的疗效。
