Centre for Global Child Health & Child Health Evaluative Sciences, Hospital for Sick Children, Toronto, Ontario, Canada
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK, Oxford, UK.
BMJ Glob Health. 2021 Mar;6(3). doi: 10.1136/bmjgh-2020-004107.
Children's growth status is an important measure commonly used as a proxy indicator of advancements in a country's health, human capital and economic development. We aimed to assess the feasibility of using Super-Imposition by Translation And Rotation (SITAR) models for summarising population-based cross-sectional height-by-age data of children under 5 years across 64 countries.
Using 145 publicly available Demographic and Health Surveys of children under 5 years across 64 low-income and middle-income countries from 2000 to 2018, we created a multicountry pseudo-longitudinal dataset of children's heights.
SITAR models including two parameters (size and intensity) explained 81% of the between-survey variation in mean boys' height and 80% in mean girls' height. Size parameters for boys and girls (relative to the WHO child growth standards) were distributed non-normally around a mean of -5.2 cm for boys (range: -7.9 cm to -1.6 cm) and -4.9 cm for girls (range: -7.7 cm to -1.2 cm). Boys exhibited 10% slower linear growth compared with the WHO (range: 19.7% slower to 1.6% faster) and girls 11% slower linear growth compared with the WHO (range: 21.4% slower to 1.0% faster). Variation in the SITAR size parameter was ≥90% explained by the combination of average length within the first 60 days of birth (as a proxy for fetal growth) and intensity, regardless of sex, with much greater contribution by postnatal intensity (r≥0.89 between size and intensity).
SITAR models with two random effects can be used to model child linear growth using multicountry pseudo-longitudinal data, and thereby provide a feasible alternative approach to summarising early childhood height trajectories based on survey data. The SITAR intensity parameter may be a novel indicator for specifically tracking progress in the determinants of postnatal growth in low-income and middle-income countries.
儿童的生长状况是衡量一个国家健康、人力资本和经济发展水平的重要指标。本研究旨在评估使用翻译旋转叠加(SITAR)模型来总结 64 个低收入和中等收入国家 5 岁以下儿童基于人群的横断面身高-年龄数据的可行性。
使用 2000 年至 2018 年期间来自 64 个低收入和中等收入国家的 145 份公开的儿童 5 岁以下人口健康调查数据,创建了一个多国伪纵向儿童身高数据集。
包含两个参数(大小和强度)的 SITAR 模型解释了男孩平均身高和女孩平均身高的 81%和 80%的调查间差异。男孩和女孩的大小参数(相对于世卫组织儿童生长标准)呈非正态分布,均值为-5.2cm(范围:-7.9cm 至-1.6cm),女孩为-4.9cm(范围:-7.7cm 至-1.2cm)。与世卫组织相比,男孩的线性生长速度慢 10%(范围:慢 19.7%至快 1.6%),女孩的线性生长速度慢 11%(范围:慢 21.4%至快 1.0%)。SITAR 大小参数的变异可以通过出生后 60 天内的平均长度(作为胎儿生长的替代指标)和强度的组合解释≥90%,与性别无关,出生后强度的贡献更大(大小和强度之间的 r 值≥0.89)。
SITAR 模型具有两个随机效应,可用于使用多国伪纵向数据对儿童线性生长进行建模,从而提供一种基于调查数据总结儿童早期身高轨迹的可行替代方法。SITAR 强度参数可能是一个新的指标,专门用于跟踪低收入和中等收入国家出生后生长决定因素的进展。