Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, USA.
Department of Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, USA.
Nat Commun. 2021 Mar 1;12(1):1358. doi: 10.1038/s41467-021-21587-5.
Data storage in DNA is a rapidly evolving technology that could be a transformative solution for the rising energy, materials, and space needs of modern information storage. Given that the information medium is DNA itself, its stability under different storage and processing conditions will fundamentally impact and constrain design considerations and data system capabilities. Here we analyze the storage conditions, molecular mechanisms, and stabilization strategies influencing DNA stability and pose specific design configurations and scenarios for future systems that best leverage the considerable advantages of DNA storage.
DNA 数据存储是一项快速发展的技术，它可能成为解决现代信息存储中能源、材料和空间需求不断增长的变革性解决方案。由于信息介质本身就是 DNA，因此其在不同存储和处理条件下的稳定性将从根本上影响和限制设计考虑因素和数据系统功能。在这里，我们分析了影响 DNA 稳定性的存储条件、分子机制和稳定化策略，并为未来的系统提出了具体的设计配置和方案，以充分利用 DNA 存储的巨大优势。
