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环丙沙星治疗地中海斑疹热。

Ciprofloxacin therapy for Mediterranean spotted fever.

作者信息

Raoult D, Gallais H, De Micco P, Casanova P

出版信息

Antimicrob Agents Chemother. 1986 Oct;30(4):606-7. doi: 10.1128/AAC.30.4.606.

DOI:10.1128/AAC.30.4.606
PMID:3789693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC176489/
Abstract

We report the treatment of five patients with Mediterranean spotted fever with the antimicrobial agent ciprofloxacin. The treatment was administered intravenously for 2 days and then perorally for 8 days. All five patients were cured. These preliminary data seem to correlate with the in vitro activity of ciprofloxacin against Rickettsia conorii.

摘要

我们报告了使用抗菌药物环丙沙星治疗5例地中海斑疹热患者的情况。治疗先静脉给药2天，然后口服给药8天。所有5例患者均治愈。这些初步数据似乎与环丙沙星对康氏立克次体的体外活性相关。

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本文引用的文献

1
[Malignant form of Mediterranean boutonneuse fever. 6 cases].
Presse Med. 1983 Oct 29;12(38):2375-8.
2
Mediterranean spotted fever: a cooperative study of 227 cases.
Rev Infect Dis. 1985 Sep-Oct;7(5):635-42. doi: 10.1093/clinids/7.5.635.
3
Mediterranean spotted fever: clinical, laboratory and epidemiological features of 199 cases.地中海斑疹热：199例临床、实验室及流行病学特征
Am J Trop Med Hyg. 1986 Jul;35(4):845-50. doi: 10.4269/ajtmh.1986.35.845.
4
Pharmacokinetics of ciprofloxacin after oral and parenteral administration.口服和肠胃外给药后环丙沙星的药代动力学。
Antimicrob Agents Chemother. 1985 Mar;27(3):375-9. doi: 10.1128/AAC.27.3.375.
5
In vitro susceptibility of Rickettsia conorii to ciprofloxacin as determined by suppressing lethality in chicken embryos and by plaque assay.通过抑制鸡胚致死率和空斑试验测定康氏立克次体对环丙沙星的体外敏感性。
Antimicrob Agents Chemother. 1986 Mar;29(3):424-5. doi: 10.1128/AAC.29.3.424.