Department of Pathology, Digestive Disease Research Institute, Wonkwang University, Iksan, Jeonbuk, 54538, Republic of Korea.
Department of Biomedical Science, Graduate School, Wonkwang University, Iksan, Jeonbuk, 54538, Republic of Korea.
Exp Mol Med. 2021 Mar;53(3):310-317. doi: 10.1038/s12276-021-00571-5. Epub 2021 Mar 1.
Zebrafish have several advantages compared to other vertebrate models used in modeling human diseases, particularly for large-scale genetic mutant and therapeutic compound screenings, and other biomedical research applications. With the impactful developments of CRISPR and next-generation sequencing technology, disease modeling in zebrafish is accelerating the understanding of the molecular mechanisms of human genetic diseases. These efforts are fundamental for the future of precision medicine because they provide new diagnostic and therapeutic solutions. This review focuses on zebrafish disease models for biomedical research, mainly in developmental disorders, mental disorders, and metabolic diseases.
斑马鱼相对于其他用于人类疾病建模的脊椎动物模型具有许多优势，特别是在大规模遗传突变体和治疗化合物筛选以及其他生物医学研究应用方面。随着 CRISPR 和下一代测序技术的发展，斑马鱼疾病模型正在加速理解人类遗传疾病的分子机制。这些努力对于精准医学的未来至关重要，因为它们提供了新的诊断和治疗解决方案。本综述重点介绍了用于生物医学研究的斑马鱼疾病模型，主要涉及发育障碍、精神障碍和代谢疾病。
