Pharmacy Department, Edward Hines Jr, Veterans' Affairs (VA) Hospital, Hines, Illinois.
Washington University School of Medicine, St Louis, Missouri.
Infect Control Hosp Epidemiol. 2021 Dec;42(12):1422-1430. doi: 10.1017/ice.2021.16. Epub 2021 Mar 2.
United States dentists prescribe 10% of all outpatient antibiotics. Assessing appropriateness of antibiotic prescribing has been challenging due to a lack of guidelines for oral infections. In 2019, the American Dental Association (ADA) published clinical practice guidelines (CPG) on the management of acute oral infections. Our objective was to describe baseline national antibiotic prescribing for acute oral infections prior to the release of the ADA CPG and to identify patient-level variables associated with an antibiotic prescription.
Cross-sectional analysis.
We performed an analysis of national VA data from January 1, 2017, to December 31, 2017. We identified cases of acute oral infections using International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM) codes. Antibiotics prescribed by a dentist within ±7 days of a visit were included. Multivariable logistic regression identified patient-level variables associated with an antibiotic prescription.
Of the 470,039 VA dental visits with oral infections coded, 12% of patient visits with irreversible pulpitis, 17% with apical periodontitis, and 28% with acute apical abscess received antibiotics. Although the median days' supply was 7, prolonged use of antibiotics was frequent (≥8 days, 42%-49%). Patients with high-risk cardiac conditions, prosthetic joints, and endodontic, implant, and oral and maxillofacial surgery dental procedures were more likely to receive antibiotics.
Most treatments of irreversible pulpitis and apical periodontitis cases were concordant with new ADA guidelines. However, in cases where antibiotics were prescribed, prolonged antibiotic courses >7 days were frequent. These findings demonstrate opportunities for the new ADA guidelines to standardize and improve dental prescribing practices.
美国牙医开出了所有门诊抗生素处方的 10%。由于缺乏口腔感染的指南,评估抗生素处方的合理性一直具有挑战性。2019 年,美国牙科协会(ADA)发布了关于急性口腔感染管理的临床实践指南(CPG)。我们的目的是描述 ADA CPG 发布前急性口腔感染的全国抗生素处方的基线情况,并确定与抗生素处方相关的患者水平变量。
横断面分析。
我们对 2017 年 1 月 1 日至 2017 年 12 月 31 日期间的全国退伍军人事务部(VA)数据进行了分析。我们使用国际疾病分类,第十次修订,临床修正版(ICD-10-CM)代码来识别急性口腔感染病例。在就诊后±7 天内由牙医开出的抗生素均包括在内。多变量逻辑回归确定了与抗生素处方相关的患者水平变量。
在所编码的 470,039 例 VA 牙科就诊中,有 12%的不可逆性牙髓炎患者、17%的根尖周炎患者和 28%的急性根尖脓肿患者接受了抗生素治疗。尽管中位数供应天数为 7 天,但抗生素的使用时间较长(≥8 天,42%-49%)。患有高风险心脏疾病、假体关节以及牙髓、种植体和口腔颌面外科牙科手术的患者更有可能接受抗生素治疗。
大多数不可逆性牙髓炎和根尖周炎病例的治疗与新的 ADA 指南一致。然而,在开出抗生素的情况下,长时间(>7 天)使用抗生素的情况很常见。这些发现表明新的 ADA 指南有机会规范和改善牙科处方实践。