13,14-二氢前列腺素F2α合成酶在大鼠卵巢中催化13,14-二氢-15-酮基前列腺素F2α转化为13,14-二氢前列腺素F2α的初步概况
Preliminary profiles of 13,14-dihydroprostaglandin F2 alpha synthetase catalyzing conversion of 13,14-dihydro-15-ketoprostaglandin F2 alpha to 13,14-dihydroprostaglandin F2 alpha in rat ovary.
作者信息
Inazu N, Harasawa Y, Satoh T
机构信息
Department of Pharmacology and Toxicology, Tokyo College of Pharmacy, Japan.
出版信息
Arch Int Pharmacodyn Ther. 1988 Jan-Feb;291:272-9.
PMID:3365066
Abstract
In the rat ovary 13,14-dihydroprostaglandin F2 alpha (13,14H2-PGF2 alpha) synthetase required NADPH much more than NADH as a co-factor. 13,14H2-PGF2 alpha synthetase activity was NADPH concentration-dependent and was significantly inhibited by NADP, in the presence of NADPH, by indomethacin and by oxidized glutathione.
摘要
在大鼠卵巢中，13,14-二氢前列腺素F2α（13,14H2-PGF2α）合成酶作为辅因子时对NADPH的需求远高于NADH。13,14H2-PGF2α合成酶活性依赖于NADPH浓度，并在存在NADPH的情况下，被NADP、吲哚美辛和氧化型谷胱甘肽显著抑制。
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