[Morphometric and electron microscopic characterization of immunocompetent cells in dysplasia and early cancer of the stomach].

Histologic, electron-microscopic and morphologic methods were employed to study the cells of the infiltrate and lymphocytes in dysplasia and early cancer of the stomach. Less numerous plasma cells and more numerous lymphocytes and macrophages were observed in the infiltrate in severe dysplasia and cancer than in mild and moderate dysplasia, no dysplasia. With growing severity of the dysplasia, cooperative activity of immunocompetent cells is on the increase, the proportion of intermediate and large lymphocytes appeared elevated. Adenocarcinoma versus severe dysplasia demonstrated reduced lymphocytic magnitude with predominance of small lymphocytes. Contrary to dysplasia, there was a macrophage cytotoxic effect observed also for large granular lymphocytes in all histologic variants of cancer, in line with stromal presentation of myofibroblasts. This can provide additional criteria by ultrastructure in differential diagnosis between severe dysplasia and initial cancer.