Kodolova I M, Kogan E A, Sekamova S M, Iashunskaia N Ia
Arkh Patol. 1988;50(1):69-73.
A case of a primary malignant mesenchymoma of the lung with elements of rhabdomyo-, leiomyo-, osteo-, fibro- and lipo-sarcoma is described. The tumor developed in a man of 58 with a long history of smoking, complaints of chest pains and cough with scanty sputum expectoration. The neoplastic process involved the upper lobe of the left lung and microscopically contained smooth muscle, endothelial, fibroblast-like cells, multinuclear giant cells resembling osteoclasts, strips of osteoid-like hyalinized connective tissue. Electron-microscopic examination revealed myoid-type cells with clusters of myofilaments and Z-type material, cells resembling fibroblasts, osteoclasts and lipocytes. It is suggested that there should be a common histogenesis of primary lung sarcomas arising from a stem cell precursor of mesenchymal origin in lung stroma, bronchial and vascular walls, pleura.
本文描述了一例具有横纹肌、平滑肌、骨、纤维和脂肪肉瘤成分的原发性肺恶性间叶瘤。该肿瘤发生于一名58岁有长期吸烟史的男性，患者主诉胸痛及咳痰少的咳嗽症状。肿瘤病变累及左肺上叶，显微镜下可见平滑肌、内皮细胞、成纤维细胞样细胞、类似破骨细胞的多核巨细胞以及类骨样玻璃样变性结缔组织条带。电子显微镜检查发现有含肌丝束和Z线物质的肌样细胞、类似成纤维细胞、破骨细胞和脂肪细胞的细胞。提示原发性肺肉瘤可能存在共同的组织发生学，起源于肺间质、支气管和血管壁、胸膜中的间充质来源干细胞前体。
