Galil-Ogly G A, Poroshin K K, Krylov L M
Arkh Patol. 1981;43(10):33-40.
Characteristics of a little-studied tumor of soft tissues are described on the basis of the author's own material (4 observations) and data from the literature. The matter at issue is a benign or malignant schwannoma (less frequently, ganglioneuroblastoma) in which there are areas of rhabdomyosarcoma and sometimes tumor elements of mesenchymal origin (angio- lipo-, or osteogenic sarcoma). As a rule, this tumor is located along the peripheral nerve or arises in one of the nodes in Recklinghausen's disease and has a trend to hematogenic metastasising. It is suggested that the source of growth of neoplasias of this kind are the cells of "neural crest" migrating in the process of embryogenesis. These cells are responsible for the formation of lemmocytes, ganglial elements and melanocytes, as well as ectomesenchyma from which, in its turn, a part of cross-striated musculature is formed. Therefore, the tumors described in the paper should be designated as "neuroectomesenchymoma" (according to some authors, ectomesenchymoma).
基于作者自己的资料(4例观察)以及文献数据,描述了一种研究较少的软组织肿瘤的特征。讨论的问题是一种良性或恶性神经鞘瘤(较少见的是神经节神经母细胞瘤),其中存在横纹肌肉瘤区域,有时还有间充质起源的肿瘤成分(血管脂肪肉瘤或骨肉瘤)。通常,这种肿瘤沿周围神经分布或发生于冯雷克林霍增氏病的一个结节中,并有血行转移倾向。提示这类肿瘤的生长来源是胚胎发育过程中迁移的“神经嵴”细胞。这些细胞负责形成雪旺细胞、神经节成分和黑素细胞,以及外间充质,进而由外间充质形成部分横纹肌组织。因此,本文所述肿瘤应命名为“神经外间充质瘤”(根据一些作者的说法,外间充质瘤)。