从金粟兰科植物金粟兰 Chloranthus henryi 中得到具有神经保护活性的倍半萜类化合物。
Sesquiterpenoids with neuroprotective activities from the Chloranthaceae plant Chloranthus henryi.
机构信息
School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, People's Republic of China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
出版信息
Fitoterapia. 2021 Jun;151:104871. doi: 10.1016/j.fitote.2021.104871. Epub 2021 Feb 27.
A rare sesquiterpenoid possessing a 6/6 bicyclic system fused with two clustered furan units and a pair of guaiane-type sesquiterpenoids were acquired from the roots of Chloranthus henryi. Their structures with absolute configurations were characterized with spectroscopic data, ECD, and X-ray diffraction analysis. All three sesquiterpenoids showed moderate neuroprotective activities on PC12 cells damaged with hydrogen peroxide.
从金粟兰科植物金粟兰 Chloranthus henryi 的根部分离得到了三个罕见的倍半萜类化合物，它们均具有 6/6 双环系统，与两个聚集的呋喃单元融合，并带有一对瓜环型倍半萜类化合物。通过光谱数据、ECD 和 X 射线衍射分析确定了它们的结构和绝对构型。这三个倍半萜类化合物均对过氧化氢损伤的 PC12 细胞显示出中等的神经保护活性。
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