School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, 330004, PR China.
School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, 330004, PR China.
Phytochemistry. 2025 Jan;229:114292. doi: 10.1016/j.phytochem.2024.114292. Epub 2024 Sep 26.
Fifteen undescribed sesquiterpenoid monomers, including six pairs of sesquiterpenoid enantiomers (1a/1b-3a/3b and 5a/5b-7a/7b) and three analogues (4, 8, and 9), together with two known sesquiterpenoid dimers (10 and 11) were isolated from the whole plant of Chloranthus henryi Hemsl. Their structures were characterized by spectroscopic data analysis, ECD calculations, and single crystal X-Ray diffractions. Compounds 1a and 1b were highly aromatic cadinane-type sesquiterpenoids. At a concentration of 10 μM, compounds 8, 10, and 11 exhibited potent neuroprotective activity against HO-induced PC12 cell damage. Compounds 10 and 11 significantly decreased the level of ROS. In addition, compound 11 increased the levels of p-AMPK, p-SIRT1, and SIRT3 in the HO-induced PC12 cell damage via activated the AMPK/SIRT signaling pathway.
从全株金粟兰中分离得到 15 个未被描述的倍半萜类单体，包括 6 对倍半萜类对映异构体（1a/1b-3a/3b 和 5a/5b-7a/7b）和 3 个类似物（4、8 和 9），以及 2 个已知的倍半萜类二聚体（10 和 11）。通过光谱数据分析、ECD 计算和单晶 X 射线衍射对它们的结构进行了表征。化合物 1a 和 1b 是高度芳香的卡丹烷型倍半萜。在 10 μM 浓度下，化合物 8、10 和 11 对 HO 诱导的 PC12 细胞损伤表现出很强的神经保护活性。化合物 10 和 11 显著降低了 ROS 的水平。此外，化合物 11 通过激活 AMPK/SIRT 信号通路，增加了 HO 诱导的 PC12 细胞损伤中 p-AMPK、p-SIRT1 和 SIRT3 的水平。
